Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study

Nicole L. Spartano, Serkalem Demissie, Jayandra J. Himali, Kimberly A. Dukes, Joanne M. Murabito, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri

Research output: Contribution to journalArticle

Abstract

Introduction: Physical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease. Methods: Cross-sectional regression analyses were performed in Framingham Heart Study Third Generation (n = 1861) and Offspring (n = 909) cohort participants assessing the association of accelerometry-measured PA with cognitive function, adjusting for age, sex, accelerometer wear time, education, occupational status/PA, and smoking status. Results: In each cohort, achieving just 10–21.4 min/day moderate-to-vigorous PA related to better executive function (P < .02); and just 10 min/day moderate-to-vigorous PA was associated with better verbal memory in middle-aged adults in the Third Generation cohort (P = .02). In older adults of the Offspring cohort, total PA (measured in steps/day) was associated with better executive function (P < .02). Discussion: PA at levels lower than the current PA Guidelines (just 10 min/day moderate-to-vigorous PA and total PA including lower intensity PA) were associated with better cognitive function.

Original languageEnglish (US)
Pages (from-to)618-626
Number of pages9
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume5
DOIs
StatePublished - 2019

Fingerprint

Cognition
Exercise
Executive Function
Accelerometry
Adult Children
Dementia
Alzheimer Disease
Cross-Sectional Studies
Smoking
Regression Analysis
Maintenance
Guidelines
Education

Keywords

  • Accelerometer
  • Cognition
  • Epidemiology
  • Executive function
  • Exercise
  • Memory
  • Moderate-to-vigorous
  • Physical activity
  • Sedentary time

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study. / Spartano, Nicole L.; Demissie, Serkalem; Himali, Jayandra J.; Dukes, Kimberly A.; Murabito, Joanne M.; Vasan, Ramachandran S.; Beiser, Alexa S.; Seshadri, Sudha.

In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 5, 2019, p. 618-626.

Research output: Contribution to journalArticle

Spartano, Nicole L. ; Demissie, Serkalem ; Himali, Jayandra J. ; Dukes, Kimberly A. ; Murabito, Joanne M. ; Vasan, Ramachandran S. ; Beiser, Alexa S. ; Seshadri, Sudha. / Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study. In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2019 ; Vol. 5. pp. 618-626.
@article{0eeb2637cbc548a29409e71276749d5c,
title = "Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study",
abstract = "Introduction: Physical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease. Methods: Cross-sectional regression analyses were performed in Framingham Heart Study Third Generation (n = 1861) and Offspring (n = 909) cohort participants assessing the association of accelerometry-measured PA with cognitive function, adjusting for age, sex, accelerometer wear time, education, occupational status/PA, and smoking status. Results: In each cohort, achieving just 10–21.4 min/day moderate-to-vigorous PA related to better executive function (P < .02); and just 10 min/day moderate-to-vigorous PA was associated with better verbal memory in middle-aged adults in the Third Generation cohort (P = .02). In older adults of the Offspring cohort, total PA (measured in steps/day) was associated with better executive function (P < .02). Discussion: PA at levels lower than the current PA Guidelines (just 10 min/day moderate-to-vigorous PA and total PA including lower intensity PA) were associated with better cognitive function.",
keywords = "Accelerometer, Cognition, Epidemiology, Executive function, Exercise, Memory, Moderate-to-vigorous, Physical activity, Sedentary time",
author = "Spartano, {Nicole L.} and Serkalem Demissie and Himali, {Jayandra J.} and Dukes, {Kimberly A.} and Murabito, {Joanne M.} and Vasan, {Ramachandran S.} and Beiser, {Alexa S.} and Sudha Seshadri",
year = "2019",
doi = "10.1016/j.trci.2019.08.007",
language = "English (US)",
volume = "5",
pages = "618--626",
journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",
issn = "2352-8737",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study

AU - Spartano, Nicole L.

AU - Demissie, Serkalem

AU - Himali, Jayandra J.

AU - Dukes, Kimberly A.

AU - Murabito, Joanne M.

AU - Vasan, Ramachandran S.

AU - Beiser, Alexa S.

AU - Seshadri, Sudha

PY - 2019

Y1 - 2019

N2 - Introduction: Physical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease. Methods: Cross-sectional regression analyses were performed in Framingham Heart Study Third Generation (n = 1861) and Offspring (n = 909) cohort participants assessing the association of accelerometry-measured PA with cognitive function, adjusting for age, sex, accelerometer wear time, education, occupational status/PA, and smoking status. Results: In each cohort, achieving just 10–21.4 min/day moderate-to-vigorous PA related to better executive function (P < .02); and just 10 min/day moderate-to-vigorous PA was associated with better verbal memory in middle-aged adults in the Third Generation cohort (P = .02). In older adults of the Offspring cohort, total PA (measured in steps/day) was associated with better executive function (P < .02). Discussion: PA at levels lower than the current PA Guidelines (just 10 min/day moderate-to-vigorous PA and total PA including lower intensity PA) were associated with better cognitive function.

AB - Introduction: Physical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease. Methods: Cross-sectional regression analyses were performed in Framingham Heart Study Third Generation (n = 1861) and Offspring (n = 909) cohort participants assessing the association of accelerometry-measured PA with cognitive function, adjusting for age, sex, accelerometer wear time, education, occupational status/PA, and smoking status. Results: In each cohort, achieving just 10–21.4 min/day moderate-to-vigorous PA related to better executive function (P < .02); and just 10 min/day moderate-to-vigorous PA was associated with better verbal memory in middle-aged adults in the Third Generation cohort (P = .02). In older adults of the Offspring cohort, total PA (measured in steps/day) was associated with better executive function (P < .02). Discussion: PA at levels lower than the current PA Guidelines (just 10 min/day moderate-to-vigorous PA and total PA including lower intensity PA) were associated with better cognitive function.

KW - Accelerometer

KW - Cognition

KW - Epidemiology

KW - Executive function

KW - Exercise

KW - Memory

KW - Moderate-to-vigorous

KW - Physical activity

KW - Sedentary time

UR - http://www.scopus.com/inward/record.url?scp=85073171129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073171129&partnerID=8YFLogxK

U2 - 10.1016/j.trci.2019.08.007

DO - 10.1016/j.trci.2019.08.007

M3 - Article

AN - SCOPUS:85073171129

VL - 5

SP - 618

EP - 626

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

SN - 2352-8737

ER -