@article{0eeb2637cbc548a29409e71276749d5c,
title = "Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study",
abstract = "Introduction: Physical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease. Methods: Cross-sectional regression analyses were performed in Framingham Heart Study Third Generation (n = 1861) and Offspring (n = 909) cohort participants assessing the association of accelerometry-measured PA with cognitive function, adjusting for age, sex, accelerometer wear time, education, occupational status/PA, and smoking status. Results: In each cohort, achieving just 10–21.4 min/day moderate-to-vigorous PA related to better executive function (P < .02); and just 10 min/day moderate-to-vigorous PA was associated with better verbal memory in middle-aged adults in the Third Generation cohort (P = .02). In older adults of the Offspring cohort, total PA (measured in steps/day) was associated with better executive function (P < .02). Discussion: PA at levels lower than the current PA Guidelines (just 10 min/day moderate-to-vigorous PA and total PA including lower intensity PA) were associated with better cognitive function.",
keywords = "Accelerometer, Cognition, Epidemiology, Executive function, Exercise, Memory, Moderate-to-vigorous, Physical activity, Sedentary time",
author = "Spartano, {Nicole L.} and Serkalem Demissie and Himali, {Jayandra J.} and Dukes, {Kimberly A.} and Murabito, {Joanne M.} and Vasan, {Ramachandran S.} and Beiser, {Alexa S.} and Sudha Seshadri",
note = "Funding Information: This investigation was supported by the Framingham Heart Study's National Heart, Lung and Blood Institute contracts ( N01-HC25195 , HHSN268201500001I , 75N92019D00031 ) with additional support from the following National Institutes of Health grants: R01-AG054076 , R01-AG049607 , R01-AG047645 , R01-HL131029 , R01-AG0081220 , R01-AG031287 , R01 AG033040 , R01 NS017950 , and UH2 NS100605 ; the Alzheimer's Association (2018-AARG-591645); and American Heart Association ( 15GPSGC24800006 and 16MCPRP30310001 ). Funding Information: Dr. Vasan is supported in part by the Evans Medical foundation and the Jay and Louis Coffman Endowment , Department of Medicine, BUSM. Funding Information: This investigation was supported by the Framingham Heart Study's National Heart, Lung and Blood Institute contracts (N01-HC25195, HHSN268201500001I, 75N92019D00031) with additional support from the following National Institutes of Health grants: R01-AG054076, R01-AG049607, R01-AG047645, R01-HL131029, R01-AG0081220, R01-AG031287, R01 AG033040, R01 NS017950, and UH2 NS100605; the Alzheimer's Association (2018-AARG-591645); and American Heart Association (15GPSGC24800006 and 16MCPRP30310001). Dr. Vasan is supported in part by the Evans Medical foundation and the Jay and Louis Coffman Endowment, Department of Medicine, BUSM. Publisher Copyright: {\textcopyright} 2019",
year = "2019",
doi = "10.1016/j.trci.2019.08.007",
language = "English (US)",
volume = "5",
pages = "618--626",
journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",
issn = "2352-8737",
publisher = "Elsevier Inc.",
}