Abundance of triacylglycerols in ganglia and their depletion in diabetic mice: Implications for the role of altered triacylglycerols in diabetic neuropathy

Hua Cheng, Shaoping Guan, Xianlin Han

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Herein, we report the first study on the mass distribution and molecular species composition of abundant triacylglycerols (TAG) in ganglia. This study demonstrates five novel findings. First, unanticipated high levels of TAG were present in all examined ganglia from multiple species (e.g. mouse, rat and rabbit). Second, ganglial TAG mass content is location-dependent. Third, the TAG mass levels in ganglia are species-specific. Fourth, dorsal root ganglial TAG mass levels in streptozotocin-induced diabetic mice are dramatically depleted relative to those found in untreated control mice. Fifth, mouse ganglial TAG mass levels decrease with age although molecular species composition is not changed. Collectively, these results indicate that TAG is an important component of ganglia and may potentially contribute to pathological alterations in peripheral neuronal function in diabetic neuropathy.

Original languageEnglish (US)
Pages (from-to)1288-1300
Number of pages13
JournalJournal of neurochemistry
Volume97
Issue number5
DOIs
StatePublished - Jun 2006
Externally publishedYes

Keywords

  • Diabetic neuropathy
  • Dorsal root ganglia
  • Electrospray ionization mass spectrometry
  • Peripheral nervous system
  • Shotgun lipidomics
  • Triacylglycerol

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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