Absence of genotoxic potential of 902MHz (GSM) and 1747MHz (DCS) wireless communication signals: In vivo two-year bioassay in B6C3F1 mice

Christina Ziemann, Heidrun Brockmeyer, Siddharth B. Reddy, Vijaylaxmi, Thomas J. Prihoda, Niels Kuster, Thomas Tillmann, Clemens Dasenbrock

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Purpose: The aim of the present investigation was to determine the incidence of micronuclei in peripheral blood erythrocytes of B6C3F1 mice that had been chronically exposed to radiofrequencies (RF) used for mobile communication. Materials and methods: 'Ferris wheels' were used to expose tube-restrained male and female mice to simulated environmental RF signals of the Global System for Mobile Communications (GSM, 902MHz) or Digital Cellular System (DCS, 1747MHz). RF signals were applied to the mice for 2 hours/day on 5 days/week for two years, at maximal whole-body-averaged specific absorption rates of 0.4, 1.3, and 4.0 W/kg body weight. Concurrent sham-exposed mice, cage controls, and positive controls injected with mitomycin C were included in this investigation. At necropsy, peripheral blood smears were prepared, and coded slides were stained using May-Grunwald-Giemsa or acridine orange. The incidence of micronuclei was recorded for each mouse in 2000 polychromatic and 2000 normochromatic erythrocytes. Results: There were no significant differences in the frequency of micronuclei between RF-exposed, sham-exposed, and cage control mice, irrespective of the staining/counting method used. Micronuclei were, however, significantly increased in polychromatic erythrocytes of the positive control mice. Conclusions: In conclusion, the data did not indicate RF-induced genotoxicity in mice after two years of exposure.

Original languageEnglish (US)
Pages (from-to)454-464
Number of pages11
JournalInternational Journal of Radiation Biology
Issue number5
StatePublished - May 2009


  • B6C3F1 mice
  • Genotoxicity
  • Micronuclei
  • Mobile phones
  • Peripheral blood
  • Radiofrequency radiation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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