Absence of frequent involvement of modifier of Min(APC) in sporadic colorectal cancer

Morton S. Kahlenberg, Daniel L. Stoler, Nicholas J. Petrelli, Miguel Rodriguez-Bigas, Thomas K. Weber, Garth R. Anderson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Mutations in the multiple intestinal neoplasia (Min) gene, the mouse homologue of the APC gene, result in the development of intestinal tumors. The degree of tumor expression is suppressed by the modifier of Min (MOM). Alterations in the MOM gene result in markedly increased tumor expression in the mouse. The human homologue of the MOM gene has been mapped to a locus on chromosome 1p35-36, but the role of the MOM gene in the development of human sporadic colorectal cancers has not been defined. Methods: The microsatellite marker D1S199 has been previously mapped to the region of the MOM gene and was used as a primer for PCR amplification. The PCR products were subjected to denaturing electrophoresis and analyzed for loss of heterozygosity (LOH) and the mismatch repair phenomenon (RER) of each tumor compared to its mucosal control. Results: 48 consecutive sporadic colorectal cancers and normal adjacent mucosa were analyzed. LOH was noted in 2 of 48 tumors and the RER phenomenon was noted in 6 of 48 tumors. Thus, 8 of 48 tumors (16.7%) showed alterations in the region of the locus of the MOM gene. There was no association between alterations in this region and TNM stage, disease-free survival, overall survival, or p53 mutation. Conclusions: Although mutation of the APC gene is an integral component of sporadic colorectal carcinogenesis, alteration in the region including the MOM gene does not appear to play a significant role in the development or clinicopathologic behavior of human sporadic colorectal tumors.

Original languageEnglish (US)
Pages (from-to)181-185
Number of pages5
JournalAnnals of Surgical Oncology
Issue number2
StatePublished - Mar 1998
Externally publishedYes


  • APC gene
  • Modifier of Min (MOM)
  • Multiple intestinal neoplasia (MIN)
  • Sporadic colorectal cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology


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