Absence of estrogenic activity in a diet that promotes estrous cyclicity in C57BL/6J mice

K. Karelus, James F Nelson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A breeder diet that shortens estrous cycles in mice has been reported to contain estrogenic substances, based on its ability to increase uterine weight of immature mice. However, the estrogenicity of the diet was inferred from uterine weight gain of immature mice that were intact. The increased uterine weight of mice on the breeder diet could thus have resulted from a precocious pubertal increase of endogenous estrogens induced by the diet rather than estrogenic substances in the diet. We therefore measured the estrogenicity of the breeder diet in ovariectomized animals. C57BL/6J mice were fed the breeder diet or a standard diet for 1 or 4 weeks. The breeder diet failed to increase uterine weights above control values for either treatment interval. Intact mice that were fed the breeder diet had twice the number of cycles of mice fed the standard diet, a confirmation of earlier studies. These results indicate that the breeder diet does not contain biologically significant estrogenic activity, and thus potentiates cyclicity by other means.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume196
Issue number3
StatePublished - 1991

Fingerprint

Periodicity
Nutrition
Inbred C57BL Mouse
Diet
Weights and Measures
Weight control
Estrous Cycle
Weight Gain
Estrogens
Animals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{ab580b8435fe41198e0e74467b22bbe1,
title = "Absence of estrogenic activity in a diet that promotes estrous cyclicity in C57BL/6J mice",
abstract = "A breeder diet that shortens estrous cycles in mice has been reported to contain estrogenic substances, based on its ability to increase uterine weight of immature mice. However, the estrogenicity of the diet was inferred from uterine weight gain of immature mice that were intact. The increased uterine weight of mice on the breeder diet could thus have resulted from a precocious pubertal increase of endogenous estrogens induced by the diet rather than estrogenic substances in the diet. We therefore measured the estrogenicity of the breeder diet in ovariectomized animals. C57BL/6J mice were fed the breeder diet or a standard diet for 1 or 4 weeks. The breeder diet failed to increase uterine weights above control values for either treatment interval. Intact mice that were fed the breeder diet had twice the number of cycles of mice fed the standard diet, a confirmation of earlier studies. These results indicate that the breeder diet does not contain biologically significant estrogenic activity, and thus potentiates cyclicity by other means.",
author = "K. Karelus and Nelson, {James F}",
year = "1991",
language = "English (US)",
volume = "196",
pages = "321--324",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "1535-3702",
publisher = "Society for Experimental Biology and Medicine",
number = "3",

}

TY - JOUR

T1 - Absence of estrogenic activity in a diet that promotes estrous cyclicity in C57BL/6J mice

AU - Karelus, K.

AU - Nelson, James F

PY - 1991

Y1 - 1991

N2 - A breeder diet that shortens estrous cycles in mice has been reported to contain estrogenic substances, based on its ability to increase uterine weight of immature mice. However, the estrogenicity of the diet was inferred from uterine weight gain of immature mice that were intact. The increased uterine weight of mice on the breeder diet could thus have resulted from a precocious pubertal increase of endogenous estrogens induced by the diet rather than estrogenic substances in the diet. We therefore measured the estrogenicity of the breeder diet in ovariectomized animals. C57BL/6J mice were fed the breeder diet or a standard diet for 1 or 4 weeks. The breeder diet failed to increase uterine weights above control values for either treatment interval. Intact mice that were fed the breeder diet had twice the number of cycles of mice fed the standard diet, a confirmation of earlier studies. These results indicate that the breeder diet does not contain biologically significant estrogenic activity, and thus potentiates cyclicity by other means.

AB - A breeder diet that shortens estrous cycles in mice has been reported to contain estrogenic substances, based on its ability to increase uterine weight of immature mice. However, the estrogenicity of the diet was inferred from uterine weight gain of immature mice that were intact. The increased uterine weight of mice on the breeder diet could thus have resulted from a precocious pubertal increase of endogenous estrogens induced by the diet rather than estrogenic substances in the diet. We therefore measured the estrogenicity of the breeder diet in ovariectomized animals. C57BL/6J mice were fed the breeder diet or a standard diet for 1 or 4 weeks. The breeder diet failed to increase uterine weights above control values for either treatment interval. Intact mice that were fed the breeder diet had twice the number of cycles of mice fed the standard diet, a confirmation of earlier studies. These results indicate that the breeder diet does not contain biologically significant estrogenic activity, and thus potentiates cyclicity by other means.

UR - http://www.scopus.com/inward/record.url?scp=0026065652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026065652&partnerID=8YFLogxK

M3 - Article

C2 - 1998008

AN - SCOPUS:0026065652

VL - 196

SP - 321

EP - 324

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 1535-3702

IS - 3

ER -