Absence of cytomegalovirus-resistance mutations after valganciclovir prophylaxis, in a prospective multicenter study of solid-organ transplant recipients

Guy Boivin, Nathalie Goyette, Christian Gilbert, Noel Roberts, Katherine Macey, Carlos Paya, Mark D. Pescovitz, Atul Humar, Ed Dominguez, Kenneth Washburn, Emily Blumberg, Barbara Alexander, Richard Freeman, Nigel Heaton, Emma Covington

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137 Scopus citations

Abstract

We investigated the emergence of cytomegalovirus (CMV) ganciclovir- resistance mutations in 301 high-risk solid-organ transplant (SOT) recipients after oral prophylaxis, for 100 days, with either valganciclovir or ganciclovir. For patients treated with ganciclovir, the incidence of CMV UL97 mutations was 1.9% (2/103) at the end of prophylaxis and 6.1% (2/33) for patients with suspected CMV disease up to 1 year after transplantation. No resistance mutations were detected in samples from valganciclovir-treated patients. Dual polymerase (UL54) and UL97 resistance mutations were not seen. Valganciclovir was associated with negligible risk of resistance and thus constitutes a useful alternative to ganciclovir prophylaxis for CMV in high-risk SOT recipients.

Original languageEnglish (US)
Pages (from-to)1615-1618
Number of pages4
JournalJournal of Infectious Diseases
Volume189
Issue number9
DOIs
StatePublished - May 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Boivin, G., Goyette, N., Gilbert, C., Roberts, N., Macey, K., Paya, C., Pescovitz, M. D., Humar, A., Dominguez, E., Washburn, K., Blumberg, E., Alexander, B., Freeman, R., Heaton, N., & Covington, E. (2004). Absence of cytomegalovirus-resistance mutations after valganciclovir prophylaxis, in a prospective multicenter study of solid-organ transplant recipients. Journal of Infectious Diseases, 189(9), 1615-1618. https://doi.org/10.1086/382753