Absence of a significant mixed lymphocyte reaction in a marsupial (Monodelphis domestica)

W. H. Stone, D. A. Bruun, E. B. Foster, G. S. Manis, E. S. Hoffman, D. G. Saphire, J. L. Vandeberg, Anthony J Infante

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Previously we reported preliminary results suggesting that the marsupial Monodelphis domestica fails to exhibit a mixed lymphocyte reaction with allogeneic lymphocytes. To test whether this observation is simply a matter of a response too weak to detect, but capable of being augmented by immunization, we performed mixed lymphocyte culture tests on 23 of these animals that had been immunized with lymphocytes. Despite the fact that all recipients were sensitized to the lymphocytes of the donors, none of the animals had a substantial mixed lymphocyte response. Significant stimulation was noted with the mitogen concanavalin A; thus, the T cells were immunologically competent. It seems likely that the failure of this species to exhibit a significant mixed lymphocyte response is due to T cells whose ontogeny differs from that of the T cells of eutherian mammals.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalLaboratory Animal Science
Volume48
Issue number2
StatePublished - 1998

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Monodelphis
Monodelphis domestica
Marsupialia
Mixed Lymphocyte Culture Test
Lymphocytes
Metatheria
lymphocytes
T-cells
T-Lymphocytes
T-lymphocytes
Animals
Concanavalin A
Mitogens
Immunization
Mammals
concanavalin A
Cell culture
ontogeny
animals
immunization

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Stone, W. H., Bruun, D. A., Foster, E. B., Manis, G. S., Hoffman, E. S., Saphire, D. G., ... Infante, A. J. (1998). Absence of a significant mixed lymphocyte reaction in a marsupial (Monodelphis domestica). Laboratory Animal Science, 48(2), 184-189.

Absence of a significant mixed lymphocyte reaction in a marsupial (Monodelphis domestica). / Stone, W. H.; Bruun, D. A.; Foster, E. B.; Manis, G. S.; Hoffman, E. S.; Saphire, D. G.; Vandeberg, J. L.; Infante, Anthony J.

In: Laboratory Animal Science, Vol. 48, No. 2, 1998, p. 184-189.

Research output: Contribution to journalArticle

Stone, WH, Bruun, DA, Foster, EB, Manis, GS, Hoffman, ES, Saphire, DG, Vandeberg, JL & Infante, AJ 1998, 'Absence of a significant mixed lymphocyte reaction in a marsupial (Monodelphis domestica)', Laboratory Animal Science, vol. 48, no. 2, pp. 184-189.
Stone WH, Bruun DA, Foster EB, Manis GS, Hoffman ES, Saphire DG et al. Absence of a significant mixed lymphocyte reaction in a marsupial (Monodelphis domestica). Laboratory Animal Science. 1998;48(2):184-189.
Stone, W. H. ; Bruun, D. A. ; Foster, E. B. ; Manis, G. S. ; Hoffman, E. S. ; Saphire, D. G. ; Vandeberg, J. L. ; Infante, Anthony J. / Absence of a significant mixed lymphocyte reaction in a marsupial (Monodelphis domestica). In: Laboratory Animal Science. 1998 ; Vol. 48, No. 2. pp. 184-189.
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