Absence of a reservoir of Epstein‐Barr virus (EBV) in normal tongue epithelium

D. R. Miller, P. L. Heard, M. P. Cagle, D. DiMaio, Y. Ench, D. G. Morrison, P. A. Eagan, M. L. Gulley, H. B. Jenson, M. P. Moyer

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


We examined human tongue epithelium and serum samples at autopsy for evidence of latent Epstein‐Barr virus (FBV) infection. Although clinical serology revealed anti‐HBV antibodies in most sera indicating past FBV infection, we found no Epstein‐Barr nuclear antigen (EBNA‐coding sequences in tongue tissue‐by polymerase chain reaction (PCR). or Epstein‐Barr‐encoded RNA (EBERI) by in situ hybridization. Tongue epithelium does not appear to be a natural reservoir for latent by EBV in immunocompetent hosts

Original languageEnglish (US)
Pages (from-to)156-160
Number of pages5
JournalJournal of Oral Pathology & Medicine
Issue number4
StatePublished - Apr 1994


  • DMA, viral, epithelium
  • Epstein‐Barr virus: keratmocytes, mouth mucosa
  • RNA, viral, serology: tongue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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