Abruptio placentae in cynomolgus macaques (Macaca fascicularis): Male bias

N. Schlabritz-Loutsevitch, A. Schenone, M. Schenone, S. Gupta, G. Hubbard, J. Zhang, G. Mari, E. Dick

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Abruptio placentae is a serious problem with a high rate of maternal and fetal mortality and documented sexual dimorphism in reoccurrence. Macaca fascicularis is a well-described reproductive model; however, there are no data available regarding sexual dimorphism in abruptio placentae in these species. Methods: A retrospective study of pathology and medical records in a large colony of M. fascicularis was performed. Placental specimens were analyzed. Results: The incidence of placenta abruptio in the colony was 15.7/1000 births. In the abruptio placentae group, male fetuses had lower placental disk length and increased femur length compared with female fetuses. The feto-pacental ratio and fetal weight were lower in the male fetuses in the abruption group compared with those in the stillbirth group without abruption placentae. Conclusion: This is the first documentation of male bias in placental and fetal development in abruptio placentae in non-human primates.

Original languageEnglish (US)
Pages (from-to)204-210
Number of pages7
JournalJournal of medical primatology
Volume42
Issue number4
DOIs
StatePublished - Aug 1 2013

Keywords

  • Complications
  • Non-human primate
  • Placenta
  • Pregnancy
  • Sexual dimorphism

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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