TY - JOUR
T1 - Abrupt Change From Propranolol to Verapamil
T2 - Safety and Feasibility in Stable Angina Pectoris
AU - Winniford, Michael D.
AU - Fulton, Kay L.
AU - Hillis, L. David
PY - 1986/4
Y1 - 1986/4
N2 - • To study the safety and feasibility of abruptly changing antianginal therapy from propranolol hydrochloride to verapamil, we gave propranolol to ten patients with stable angina and coronary artery disease for 14 days, then, on day 15, we began verapamil therapy, which continued for 14 more days. Anginal frequency and nitroglycerin use were similar throughout the study. No patient had symptomatic bradycardia or atrioventricular block. Such crossover therapy is effective when propranolol is replaced by verapamil abruptly.
AB - • To study the safety and feasibility of abruptly changing antianginal therapy from propranolol hydrochloride to verapamil, we gave propranolol to ten patients with stable angina and coronary artery disease for 14 days, then, on day 15, we began verapamil therapy, which continued for 14 more days. Anginal frequency and nitroglycerin use were similar throughout the study. No patient had symptomatic bradycardia or atrioventricular block. Such crossover therapy is effective when propranolol is replaced by verapamil abruptly.
UR - http://www.scopus.com/inward/record.url?scp=0022550715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022550715&partnerID=8YFLogxK
U2 - 10.1001/archinte.1986.00360160247033
DO - 10.1001/archinte.1986.00360160247033
M3 - Article
C2 - 3963962
AN - SCOPUS:0022550715
VL - 146
JO - JAMA Internal Medicine
JF - JAMA Internal Medicine
SN - 2168-6106
IS - 4
ER -