Abrupt Change From Propranolol to Verapamil: Safety and Feasibility in Stable Angina Pectoris

Michael D. Winniford, Kay L. Fulton, L. David Hillis

Research output: Contribution to journalArticle


• To study the safety and feasibility of abruptly changing antianginal therapy from propranolol hydrochloride to verapamil, we gave propranolol to ten patients with stable angina and coronary artery disease for 14 days, then, on day 15, we began verapamil therapy, which continued for 14 more days. Anginal frequency and nitroglycerin use were similar throughout the study. No patient had symptomatic bradycardia or atrioventricular block. Such crossover therapy is effective when propranolol is replaced by verapamil abruptly.

Original languageEnglish (US)
Number of pages1
JournalArchives of Internal Medicine
Issue number4
StatePublished - Apr 1986


ASJC Scopus subject areas

  • Internal Medicine

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