Abnormalities of serum amylase and lipase in HIV-positive patients

Athanassios Argiris, Usha Mathur-Wagh, Ilene Wilets, Donna Mildvan

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


OBJECTIVE: We sought to study asymptomatic pancreatic enzyme abnormalities in patients with human immunodeficiency virus (HIV) infection. METHODS: Serial serum amylase and lipase determinations were performed in ambulatory HIV-seropositive patients in whom pancreatitis was not suspected. RESULTS: Eighty-six patients were enrolled in the study. Fifty-two patients (60%) were found to have abnormal amylase or lipase values on at least one determination. Only 12 (14% of all patients) had a more than twofold elevation of pancreatic enzymes. Seven patients had transient elevations of lipase within 3 months after the initiation of antiretroviral therapy. Independent factors associated with abnormal pancreatic enzymes were: positive serology for chronic hepatitis B or C, history of intravenous cotrimoxazole administration for the treatment of Pneumocystis carinii pneumonia, stage B of HIV disease, and HIV risk factors other than male homosexuality (mainly intravenous drug use). None of the patients developed clinical pancreatitis. CONCLUSIONS: Asymptomatic mild to moderate elevations of amylase or lipase are common in HIV-positive patients, and are usually associated with positive serology for chronic hepatitis B or C, and medications, especially antiretrovirals and intravenous cotrimoxazole.

Original languageEnglish (US)
Pages (from-to)1248-1252
Number of pages5
JournalAmerican Journal of Gastroenterology
Issue number5
StatePublished - May 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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