Abnormalities in serum chemokine levels in euthymic patients with Bipolar Disorder

Elisa Brietzke, Márcia Kauer-Sant'Anna, Antônio Lúcio Teixeira, Flávio Kapczinski

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

The pathophysiology of bipolar disorder (BD) includes, among other processes, changes in the neuroplasticity and regulation of apoptosis, which could potentially be influenced by inflammatory mediators such as chemokines. The objectives of this study were to investigate serum chemokine levels in patients with BD and to compare results with those obtained with healthy subjects. Here, serum chemokine levels of 30 euthymic patients with BD type I and 30 healthy volunteers were investigated and compared. The chemokines assessed were CCL2, CCL3, CCL8, CCL 9, CCL10, CCL11, and CCL24. Patients with BD showed significant differences in chemokine levels when compared with healthy subjects. While serum levels of CXCL10 were increased (p = .018), CCL24 levels were lower in bipolar patients (p = .025) when compared with controls. There was no statistical difference in the serum levels of CCL2, CCL3, CCL24, CXCL9, and CXCL11 between patients and controls. The presence of chemokine abnormalities in patients with BD during euthymia suggests that these inflammatory mediators should be further investigated with regard to their potential role as longstanding markers of the disorder.

Original languageEnglish (US)
Pages (from-to)1079-1082
Number of pages4
JournalBrain, Behavior, and Immunity
Volume23
Issue number8
DOIs
StatePublished - Nov 2009
Externally publishedYes

Keywords

  • Allostatic load
  • Bipolar disorder
  • Chemokine CXCL10
  • Chemokine CXCL24
  • Chemokines
  • Cytokines
  • Depressive episode
  • Inflammatory mediators
  • Mania
  • Neuroplasticity

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

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