@article{e0d5132e7e8d4bd3a991cee570e4a519,
title = "Abnormal neural response to phonological working memory demands in persistent developmental stuttering",
abstract = "Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulation, is known to play an important role in speech production, leading us to postulate that the neurophysiological mechanisms underlying stuttering may be associated with a WM deficit. Using functional magnetic resonance imaging, we aimed to elucidate brain mechanisms in a phonological WM task in adults who stutter and controls. A right-lateralized compensatory mechanism for a deficit in the rehearsal process and neural disconnections associated with the central executive dysfunction were found. Furthermore, the neural abnormalities underlying the phonological WM were independent of memory load. This study demonstrates for the first time the atypical neural responses to phonological WM in PWS, shedding new light on the underlying cause of stuttering.",
keywords = "brain activation, developmental stuttering, functional connectivity, phonological working memory",
author = "Yang Yang and Fanlu Jia and Fox, {Peter T.} and Siok, {Wai Ting} and Tan, {Li Hai}",
note = "Funding Information: information the Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant, Grant/Award Number: 2016ZT06S220; the Shenzhen Fundamental Research Project, Grant/Award Number: JCYJ20170307155304424, JCYJ20170818110103216, JCYJ20170818110126127, JCYJ20170818110022721, JCYJ20160608173106220 and JCYJ20170412164413575; the Shenzhen Peacock Plan, Grant/Award Number: KQTD2015033016104926We thank all the participants who participated in this study. We also thank Guiping Xu, Ke Zhou, Haiqing Du, and Junting Wang for their help with the experiments. This work was supported by the Shenzhen Peacock Plan (KQTD2015033016104926), the Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant (2016ZT06S220) and the Shenzhen Fundamental Research Project (JCYJ20170307155304424, JCYJ20170818110103216, JCYJ20170818110126127, JCYJ20170818110022721, JCYJ20160608173106220, and JCYJ20170412164413575). Funding Information: We thank all the participants who participated in this study. We also thank Guiping Xu, Ke Zhou, Haiqing Du, and Junting Wang for their help with the experiments. This work was supported by the Shenzhen Peacock Plan (KQTD2015033016104926), the Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant (2016ZT06S220) and the Shenzhen Fundamental Research Project (JCYJ20170307155304424, JCYJ20170818110103216, JCYJ20170818110126127, JCYJ20170818 110022721, JCYJ20160608173106220, and JCYJ2017041216 4413575). Funding Information: the Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant , Grant/Award Number: 2016ZT06S220; the Shenzhen Fundamental Research Project , Grant/Award Number: JCYJ20170307155304424, JCYJ20170818110103216, JCYJ20170818110126127, JCYJ20170818110022721, JCYJ20160608173106220 and JCYJ20170412164413575; the Shenzhen Peacock Plan, Grant/Award Number: KQTD2015033016104926 Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2019",
month = jan,
doi = "10.1002/hbm.24366",
language = "English (US)",
volume = "40",
pages = "214--225",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "1",
}