Abnormal neural response to phonological working memory demands in persistent developmental stuttering

Yang Yang, Fanlu Jia, Peter T. Fox, Wai Ting Siok, Li Hai Tan

Research output: Contribution to journalArticle

Abstract

Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulation, is known to play an important role in speech production, leading us to postulate that the neurophysiological mechanisms underlying stuttering may be associated with a WM deficit. Using functional magnetic resonance imaging, we aimed to elucidate brain mechanisms in a phonological WM task in adults who stutter and controls. A right-lateralized compensatory mechanism for a deficit in the rehearsal process and neural disconnections associated with the central executive dysfunction were found. Furthermore, the neural abnormalities underlying the phonological WM were independent of memory load. This study demonstrates for the first time the atypical neural responses to phonological WM in PWS, shedding new light on the underlying cause of stuttering.

LanguageEnglish (US)
JournalHuman Brain Mapping
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Stuttering
Short-Term Memory
Memory Disorders
Nervous System Diseases
Information Systems
Maintenance
Magnetic Resonance Imaging
Brain

Keywords

  • brain activation
  • developmental stuttering
  • functional connectivity
  • phonological working memory

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Abnormal neural response to phonological working memory demands in persistent developmental stuttering. / Yang, Yang; Jia, Fanlu; Fox, Peter T.; Siok, Wai Ting; Tan, Li Hai.

In: Human Brain Mapping, 01.01.2018.

Research output: Contribution to journalArticle

@article{e0d5132e7e8d4bd3a991cee570e4a519,
title = "Abnormal neural response to phonological working memory demands in persistent developmental stuttering",
abstract = "Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulation, is known to play an important role in speech production, leading us to postulate that the neurophysiological mechanisms underlying stuttering may be associated with a WM deficit. Using functional magnetic resonance imaging, we aimed to elucidate brain mechanisms in a phonological WM task in adults who stutter and controls. A right-lateralized compensatory mechanism for a deficit in the rehearsal process and neural disconnections associated with the central executive dysfunction were found. Furthermore, the neural abnormalities underlying the phonological WM were independent of memory load. This study demonstrates for the first time the atypical neural responses to phonological WM in PWS, shedding new light on the underlying cause of stuttering.",
keywords = "brain activation, developmental stuttering, functional connectivity, phonological working memory",
author = "Yang Yang and Fanlu Jia and Fox, {Peter T.} and Siok, {Wai Ting} and Tan, {Li Hai}",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/hbm.24366",
language = "English (US)",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Abnormal neural response to phonological working memory demands in persistent developmental stuttering

AU - Yang, Yang

AU - Jia, Fanlu

AU - Fox, Peter T.

AU - Siok, Wai Ting

AU - Tan, Li Hai

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulation, is known to play an important role in speech production, leading us to postulate that the neurophysiological mechanisms underlying stuttering may be associated with a WM deficit. Using functional magnetic resonance imaging, we aimed to elucidate brain mechanisms in a phonological WM task in adults who stutter and controls. A right-lateralized compensatory mechanism for a deficit in the rehearsal process and neural disconnections associated with the central executive dysfunction were found. Furthermore, the neural abnormalities underlying the phonological WM were independent of memory load. This study demonstrates for the first time the atypical neural responses to phonological WM in PWS, shedding new light on the underlying cause of stuttering.

AB - Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulation, is known to play an important role in speech production, leading us to postulate that the neurophysiological mechanisms underlying stuttering may be associated with a WM deficit. Using functional magnetic resonance imaging, we aimed to elucidate brain mechanisms in a phonological WM task in adults who stutter and controls. A right-lateralized compensatory mechanism for a deficit in the rehearsal process and neural disconnections associated with the central executive dysfunction were found. Furthermore, the neural abnormalities underlying the phonological WM were independent of memory load. This study demonstrates for the first time the atypical neural responses to phonological WM in PWS, shedding new light on the underlying cause of stuttering.

KW - brain activation

KW - developmental stuttering

KW - functional connectivity

KW - phonological working memory

UR - http://www.scopus.com/inward/record.url?scp=85052441692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052441692&partnerID=8YFLogxK

U2 - 10.1002/hbm.24366

DO - 10.1002/hbm.24366

M3 - Article

JO - Human Brain Mapping

T2 - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

ER -