Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder

A magnetic resonance imaging study

Hua Hsua Chen, Mark A. Nicoletti, John P. Hatch, Roberto B. Sassi, David Axelson, Paolo Brambilla, E. Serap Monkul, Matcheri S. Keshavan, Neal D. Ryan, Boris Birmaher, Jair C. Soares

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Abnormalities in left superior temporal gyrus (STG) have been reported in adult bipolar patients. However, it is not known whether such abnormalities are already present early in the course of this illness. Magnetic resonance imaging (MRI) morphometric analysis of STG was performed in 16 DSM-IV children and adolescents with bipolar disorder (mean age±SD 15.5±3.4 years) and 21 healthy controls (mean age±SD 16.9±3.8 years). Subjects underwent a 3D spoiled gradient recalled acquisition MRI examination. Using analysis of covariance with age, gender and intra-cranial brain volume as covariates, we found significantly smaller left total STG volumes in bipolar patients (12.5±1.5 cm3) compared with healthy controls (13.6±2.5 cm3) (F=4.45, d.f.=1,32, P=0.04). This difference was accounted for by significantly smaller left and right STG white matter volumes in bipolar patients. Decreased white matter connections may be the core of abnormalities in STG, which is an important region for speech, language and communication, and could possibly underlie neurocognitive deficits present in bipolar patients.

Original languageEnglish (US)
Pages (from-to)65-68
Number of pages4
JournalNeuroscience Letters
Volume363
Issue number1
DOIs
StatePublished - Jun 3 2004

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Temporal Lobe
Bipolar Disorder
Magnetic Resonance Imaging
Diagnostic and Statistical Manual of Mental Disorders
Language
Communication
Brain
White Matter

Keywords

  • Adolescents
  • Bipolar disorder
  • Magnetic resonance imaging
  • Superior temporal gyrus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chen, H. H., Nicoletti, M. A., Hatch, J. P., Sassi, R. B., Axelson, D., Brambilla, P., ... Soares, J. C. (2004). Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: A magnetic resonance imaging study. Neuroscience Letters, 363(1), 65-68. https://doi.org/10.1016/j.neulet.2004.03.042

Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder : A magnetic resonance imaging study. / Chen, Hua Hsua; Nicoletti, Mark A.; Hatch, John P.; Sassi, Roberto B.; Axelson, David; Brambilla, Paolo; Monkul, E. Serap; Keshavan, Matcheri S.; Ryan, Neal D.; Birmaher, Boris; Soares, Jair C.

In: Neuroscience Letters, Vol. 363, No. 1, 03.06.2004, p. 65-68.

Research output: Contribution to journalArticle

Chen, HH, Nicoletti, MA, Hatch, JP, Sassi, RB, Axelson, D, Brambilla, P, Monkul, ES, Keshavan, MS, Ryan, ND, Birmaher, B & Soares, JC 2004, 'Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: A magnetic resonance imaging study', Neuroscience Letters, vol. 363, no. 1, pp. 65-68. https://doi.org/10.1016/j.neulet.2004.03.042
Chen, Hua Hsua ; Nicoletti, Mark A. ; Hatch, John P. ; Sassi, Roberto B. ; Axelson, David ; Brambilla, Paolo ; Monkul, E. Serap ; Keshavan, Matcheri S. ; Ryan, Neal D. ; Birmaher, Boris ; Soares, Jair C. / Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder : A magnetic resonance imaging study. In: Neuroscience Letters. 2004 ; Vol. 363, No. 1. pp. 65-68.
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