Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure

J. K. Gwathmey, L. Copelas, R. MacKinnon, F. J. Schoen, M. D. Feldman, W. Grossman, J. P. Morgan

Research output: Contribution to journalArticle

754 Scopus citations

Abstract

Intracellular Ca2+ release and reuptake are essential for contraction and relaxation of normal heart muscle. Intracellular Ca2+ transients were recorded with aequorin during isometric contraction of myocardium from patients with end-stage heart failure. In contrast to controls, contractions and Ca2+ transients of muscles from failing hearts were markedly prolonged, and the Ca2+ transients exhibited 2 distinct components. Muscles from failing hearts showed a diminished capacity to restore low resting Ca2+ levels during diastole. These experiments provide the first direct evidence from actively contracting human myocardium that intracellular Ca2+ handling is abnormal and may cause systolic and diastolic dysfunction in heart failure.

Original languageEnglish (US)
Pages (from-to)70-76
Number of pages7
JournalCirculation research
Volume61
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Gwathmey, J. K., Copelas, L., MacKinnon, R., Schoen, F. J., Feldman, M. D., Grossman, W., & Morgan, J. P. (1987). Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circulation research, 61(1), 70-76. https://doi.org/10.1161/01.RES.61.1.70