Abnormal degradation of erythrocyte membrane proteins in hereditary spherocytosis

Maria Gaczyńska, Grzegorz Bartosz, Luba Judkiewicz, Janusz Rosin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The degradation rate of erythrocyte membrane proteins by membrane-bound proteases was compared in healthy controls and in patients with hereditary spherocytosis (HS). An increased degradation rate of spectrin and a decreased digestion rate of Band 3 were found in HS patients. These differences may be due to altered accessibilities of membrane proteins to proteases and/or to changes in the pattern of membrane-associated proteases and may be connected with the decrease in the spectrin : Band 3 ratio reported for erythrocyte membranes in HS.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalClinica Chimica Acta
Volume168
Issue number1
DOIs
StatePublished - Sep 15 1987
Externally publishedYes

Keywords

  • Electrophoresis
  • Erythrocyte
  • Hereditary spherocytosis
  • Membrane protein
  • Proteolysis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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