Abnormal degradation of erythrocyte membrane proteins in hereditary spherocytosis

Maria Gaczyńska; Grzegorz Bartosz; Luba Judkiewicz; Janusz Rosin

doi:10.1016/0009-8981(87)90260-9

Abnormal degradation of erythrocyte membrane proteins in hereditary spherocytosis

Maria Gaczyńska, Grzegorz Bartosz, Luba Judkiewicz, Janusz Rosin

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The degradation rate of erythrocyte membrane proteins by membrane-bound proteases was compared in healthy controls and in patients with hereditary spherocytosis (HS). An increased degradation rate of spectrin and a decreased digestion rate of Band 3 were found in HS patients. These differences may be due to altered accessibilities of membrane proteins to proteases and/or to changes in the pattern of membrane-associated proteases and may be connected with the decrease in the spectrin : Band 3 ratio reported for erythrocyte membranes in HS.

Original language	English (US)
Pages (from-to)	7-11
Number of pages	5
Journal	Clinica Chimica Acta
Volume	168
Issue number	1
DOIs	https://doi.org/10.1016/0009-8981(87)90260-9
State	Published - Sep 15 1987
Externally published	Yes

Keywords

Electrophoresis
Erythrocyte
Hereditary spherocytosis
Membrane protein
Proteolysis

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Biochemistry, medical

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10.1016/0009-8981(87)90260-9

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abstract = "The degradation rate of erythrocyte membrane proteins by membrane-bound proteases was compared in healthy controls and in patients with hereditary spherocytosis (HS). An increased degradation rate of spectrin and a decreased digestion rate of Band 3 were found in HS patients. These differences may be due to altered accessibilities of membrane proteins to proteases and/or to changes in the pattern of membrane-associated proteases and may be connected with the decrease in the spectrin : Band 3 ratio reported for erythrocyte membranes in HS.",

keywords = "Electrophoresis, Erythrocyte, Hereditary spherocytosis, Membrane protein, Proteolysis",

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T1 - Abnormal degradation of erythrocyte membrane proteins in hereditary spherocytosis

AU - Gaczyńska, Maria

AU - Bartosz, Grzegorz

AU - Judkiewicz, Luba

AU - Rosin, Janusz

PY - 1987/9/15

Y1 - 1987/9/15

N2 - The degradation rate of erythrocyte membrane proteins by membrane-bound proteases was compared in healthy controls and in patients with hereditary spherocytosis (HS). An increased degradation rate of spectrin and a decreased digestion rate of Band 3 were found in HS patients. These differences may be due to altered accessibilities of membrane proteins to proteases and/or to changes in the pattern of membrane-associated proteases and may be connected with the decrease in the spectrin : Band 3 ratio reported for erythrocyte membranes in HS.

AB - The degradation rate of erythrocyte membrane proteins by membrane-bound proteases was compared in healthy controls and in patients with hereditary spherocytosis (HS). An increased degradation rate of spectrin and a decreased digestion rate of Band 3 were found in HS patients. These differences may be due to altered accessibilities of membrane proteins to proteases and/or to changes in the pattern of membrane-associated proteases and may be connected with the decrease in the spectrin : Band 3 ratio reported for erythrocyte membranes in HS.

KW - Electrophoresis

KW - Erythrocyte

KW - Hereditary spherocytosis

KW - Membrane protein

KW - Proteolysis

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JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

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Abnormal degradation of erythrocyte membrane proteins in hereditary spherocytosis

Abstract

Keywords

ASJC Scopus subject areas

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