Aberrant subcellular localization of BRCA1 in breast cancer

Yumay Chen, Chi Fen Chen, Daniel J. Riley, D. Craig Allred, Phang Lang Chen, Daniel Von Hoff, C. Kent Osborne, Wen Hwa Lee

Research output: Contribution to journalArticlepeer-review

309 Scopus citations


The BRCA1 gene product was identified as a 220-kilodalton nuclear phosphoprotein in normal cells, including breast ductal epithelial cells, and in 18 of 20 tumor cell lines derived from tissues other than breast and ovary. In 16 of 17 breast and ovarian cancer lines and 17 of 17 samples of cells obtained from malignant effusions, however, BRCA1 localized mainly in cytoplasm. Absence of BRCA1 or aberrant subcellular location was also observed to a variable extent in histological sections of many breast cancer biopsies. These findings suggest that BRCA1 abnormalities may be involved in the pathogenesis of many breast cancers, sporadic as well as familial.

Original languageEnglish (US)
Pages (from-to)789-791
Number of pages3
Issue number5237
StatePublished - 1995

ASJC Scopus subject areas

  • General


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