Aberrant Expression of the Myeloid Zinc Finger Gene, MZF-1, Is Oncogenic

Robert Hromas, Jennifer Morris, Kenneth Cornetta, Douglas Berebitsky, Amy Davidson, Michael Sha, George Sledge, Frank Rauscher

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The zinc finger gene MZF-1 is preferentially expressed in primitive hematopoietic cells and plays an important role in regulating myelopoie-sis. Regulators of development are potential targets for neoplastic transformation. This study investigated whether unregulated expression of MZF-1 could function as an oncogene. Retroviral transduction and subsequent overexpression of MZF-1 resulted in loss of contact inhibition, loss of substrate dependence, and more rapid cell cycling in NIH 3T3 cells. The MZF-1-transformed 3T3 cells formed aggressive tumors in athymic mice. Disruption of the tight lineage- and stage-specific regulation of MZF-1 can result in neoplastic transformation of embryonic fibroblasts. Therefore, MZF-1 represents a novel oncogene.

Original languageEnglish (US)
Pages (from-to)3610-3614
Number of pages5
JournalCancer Research
Volume55
Issue number16
StatePublished - Aug 15 1995
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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