Aberrant epigenetic modifications in radiation-resistant head and neck cancers

Hon Yi Lin; Tim Hui Ming Huang; Michael Wing Yan Chan

doi:10.1007/978-1-4939-1804-1_17

Aberrant epigenetic modifications in radiation-resistant head and neck cancers

Hon Yi Lin
, Tim Hui Ming Huang
, Michael Wing Yan Chan

Department of Molecular Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Head and neck cancers are characterized by both genetic and epigenetic aberrations. In treating head and neck cancers, ionizing radiation (IR) is an essential modality in either definitive or adjuvant setting. However, radiation-resistant head and neck cancers are not uncommon. The major biological determinator for IR resistance was previously considered at genetic level because DNA is the major target of irradiation damage. However, in head and neck cancers, recent evidence demonstrated epigenetic disturbance after IR, implicating its role in IR resistance. Hence, this chapter intends to establish an in vitro model for investigating DNA methylation changes in IR-resistant head and neck cancer cells. Bisulfite pyrosequencing is the main methodology it introduced.

Original language	English (US)
Title of host publication	Cancer Epigenetics
Subtitle of host publication	Risk Assessment, Diagnosis, Treatment, and Prognosis
Publisher	Springer New York
Pages	321-332
Number of pages	12
ISBN (Electronic)	9781493918041
ISBN (Print)	9781493918034
DOIs	https://doi.org/10.1007/978-1-4939-1804-1_17
State	Published - Nov 24 2014

Keywords

DNA methylation
Epigenetics
Head and neck cancers
Histone modification
Ionizing radiation
MicroRNA
Radioresistance
Radiosensitivity

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4939-1804-1_17

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abstract = "Head and neck cancers are characterized by both genetic and epigenetic aberrations. In treating head and neck cancers, ionizing radiation (IR) is an essential modality in either definitive or adjuvant setting. However, radiation-resistant head and neck cancers are not uncommon. The major biological determinator for IR resistance was previously considered at genetic level because DNA is the major target of irradiation damage. However, in head and neck cancers, recent evidence demonstrated epigenetic disturbance after IR, implicating its role in IR resistance. Hence, this chapter intends to establish an in vitro model for investigating DNA methylation changes in IR-resistant head and neck cancer cells. Bisulfite pyrosequencing is the main methodology it introduced.",

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AU - Lin, Hon Yi

AU - Huang, Tim Hui Ming

AU - Chan, Michael Wing Yan

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N2 - Head and neck cancers are characterized by both genetic and epigenetic aberrations. In treating head and neck cancers, ionizing radiation (IR) is an essential modality in either definitive or adjuvant setting. However, radiation-resistant head and neck cancers are not uncommon. The major biological determinator for IR resistance was previously considered at genetic level because DNA is the major target of irradiation damage. However, in head and neck cancers, recent evidence demonstrated epigenetic disturbance after IR, implicating its role in IR resistance. Hence, this chapter intends to establish an in vitro model for investigating DNA methylation changes in IR-resistant head and neck cancer cells. Bisulfite pyrosequencing is the main methodology it introduced.

AB - Head and neck cancers are characterized by both genetic and epigenetic aberrations. In treating head and neck cancers, ionizing radiation (IR) is an essential modality in either definitive or adjuvant setting. However, radiation-resistant head and neck cancers are not uncommon. The major biological determinator for IR resistance was previously considered at genetic level because DNA is the major target of irradiation damage. However, in head and neck cancers, recent evidence demonstrated epigenetic disturbance after IR, implicating its role in IR resistance. Hence, this chapter intends to establish an in vitro model for investigating DNA methylation changes in IR-resistant head and neck cancer cells. Bisulfite pyrosequencing is the main methodology it introduced.

KW - DNA methylation

KW - Epigenetics

KW - Head and neck cancers

KW - Histone modification

KW - Ionizing radiation

KW - MicroRNA

KW - Radioresistance

KW - Radiosensitivity

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M3 - Chapter

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SN - 9781493918034

SP - 321

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BT - Cancer Epigenetics

PB - Springer New York

ER -

Aberrant epigenetic modifications in radiation-resistant head and neck cancers

Abstract

Keywords

ASJC Scopus subject areas

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