Aberrant crypt foci: The case for inclusion as a biomarker for colon cancer

Michael J Wargovich, Vondina R. Brown, James L Morris

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.

Original languageEnglish (US)
Pages (from-to)1705-1716
Number of pages12
JournalCancers
Volume2
Issue number3
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Aberrant Crypt Foci
Colonic Neoplasms
Biomarkers
Neoplasms

Keywords

  • Aberrant crypt foci
  • Biomarker
  • Chemoprevention
  • Colon cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Aberrant crypt foci : The case for inclusion as a biomarker for colon cancer. / Wargovich, Michael J; Brown, Vondina R.; Morris, James L.

In: Cancers, Vol. 2, No. 3, 09.2010, p. 1705-1716.

Research output: Contribution to journalArticle

Wargovich, Michael J ; Brown, Vondina R. ; Morris, James L. / Aberrant crypt foci : The case for inclusion as a biomarker for colon cancer. In: Cancers. 2010 ; Vol. 2, No. 3. pp. 1705-1716.
@article{0edf156277a4444db0eb407beba3c5d0,
title = "Aberrant crypt foci: The case for inclusion as a biomarker for colon cancer",
abstract = "Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.",
keywords = "Aberrant crypt foci, Biomarker, Chemoprevention, Colon cancer",
author = "Wargovich, {Michael J} and Brown, {Vondina R.} and Morris, {James L}",
year = "2010",
month = "9",
doi = "10.3390/cancers2031705",
language = "English (US)",
volume = "2",
pages = "1705--1716",
journal = "Cancers",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

TY - JOUR

T1 - Aberrant crypt foci

T2 - The case for inclusion as a biomarker for colon cancer

AU - Wargovich, Michael J

AU - Brown, Vondina R.

AU - Morris, James L

PY - 2010/9

Y1 - 2010/9

N2 - Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.

AB - Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.

KW - Aberrant crypt foci

KW - Biomarker

KW - Chemoprevention

KW - Colon cancer

UR - http://www.scopus.com/inward/record.url?scp=79952256046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952256046&partnerID=8YFLogxK

U2 - 10.3390/cancers2031705

DO - 10.3390/cancers2031705

M3 - Article

AN - SCOPUS:79952256046

VL - 2

SP - 1705

EP - 1716

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 3

ER -