Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid

Khashayarsha Khazaie; Mojgan Zadeh; Mohammad W. Khan; Praveen Bere; Fotini Gounari; Kirsten Dennis; Nichole R. Blatner; Jennifer L. Owen; Todd R. Klaenhammer; Mansour Mohamadzadeh

doi:10.1073/pnas.1207230109

Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid

Khashayarsha Khazaie, Mojgan Zadeh, Mohammad W. Khan, Praveen Bere, Fotini Gounari, Kirsten Dennis, Nichole R. Blatner, Jennifer L. Owen, Todd R. Klaenhammer, Mansour Mohamadzadeh

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

An imbalance of commensal bacteria and their gene products underlies mucosal and, in particular, gastrointestinal inflammation and a predisposition to cancer. Lactobacillus species have received considerable attention as examples of beneficial microbiota. We have reported previously that deletion of the phosphoglycerol transferase gene that is responsible for lipoteichoic acid (LTA) biosynthesis in Lactobacillus acidophilus (NCK2025) rendered this bacterium able to significantly protect mice against induced colitis when delivered orally. Here we report that oral treatment with LTA-deficient NCK2025 normalizes innate and adaptive pathogenic immune responses and causes regression of established colonic polyps. This study reveals the proinflammatory role of LTA and the ability of LTA-deficient L. acidophilus to regulate inflammation and protect against colonic polyposis in a unique mouse model.

Original language	English (US)
Pages (from-to)	10462-10467
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	109
Issue number	26
DOIs	https://doi.org/10.1073/pnas.1207230109
State	Published - Jun 26 2012
Externally published	Yes

Keywords

Anti-inflammatory
Dendritic cells
Regulatory T cells

ASJC Scopus subject areas

General

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10.1073/pnas.1207230109

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Khazaie, K., Zadeh, M., Khan, M. W., Bere, P., Gounari, F., Dennis, K., Blatner, N. R., Owen, J. L., Klaenhammer, T. R., & Mohamadzadeh, M. (2012). Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid. Proceedings of the National Academy of Sciences of the United States of America, 109(26), 10462-10467. https://doi.org/10.1073/pnas.1207230109

Khazaie, K, Zadeh, M, Khan, MW, Bere, P, Gounari, F, Dennis, K, Blatner, NR, Owen, JL, Klaenhammer, TR & Mohamadzadeh, M 2012, 'Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 26, pp. 10462-10467. https://doi.org/10.1073/pnas.1207230109

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abstract = "An imbalance of commensal bacteria and their gene products underlies mucosal and, in particular, gastrointestinal inflammation and a predisposition to cancer. Lactobacillus species have received considerable attention as examples of beneficial microbiota. We have reported previously that deletion of the phosphoglycerol transferase gene that is responsible for lipoteichoic acid (LTA) biosynthesis in Lactobacillus acidophilus (NCK2025) rendered this bacterium able to significantly protect mice against induced colitis when delivered orally. Here we report that oral treatment with LTA-deficient NCK2025 normalizes innate and adaptive pathogenic immune responses and causes regression of established colonic polyps. This study reveals the proinflammatory role of LTA and the ability of LTA-deficient L. acidophilus to regulate inflammation and protect against colonic polyposis in a unique mouse model.",

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Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid

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