A walnut-enriched diet reduces the growth of LNCaP human prostate cancer xenografts in nude mice

Russel J. Reiter, Dun Xian Tan, Lucien C. Manchester, Ahmet Korkmaz, Lorena Fuentes-Broto, W. Elaine Hardman, Sergio A. Rosales-Corral, Wenbo Qi

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

It was investigated whether a standard mouse diet (AIN-76A) supplemented with walnuts reduced the establishment and growth of LNCaP human prostate cancer cells in nude (nu/nu) mice. The walnut-enriched diet reduced the number of tumors and the growth of the LNCaP xenografts; 3 of 16 (18.7%) of the walnut-fed mice developed tumors; conversely, 14 of 32 mice (44.0%) of the control diet-fed animals developed tumors. Similarly, the xenografts in the walnut-fed animals grew more slowly than those in the control diet mice. The final average tumor size in the walnut-diet animals was roughly one-fourth the average size of the prostate tumors in the mice that ate the control diet.

Original languageEnglish (US)
Pages (from-to)365-373
Number of pages9
JournalCancer Investigation
Volume31
Issue number6
DOIs
StatePublished - Jul 2013

Keywords

  • F2-isoprostanes
  • LNCaP cells
  • Prostate cancer
  • Walnuts

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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