A variance component approach to dichotomous trait linkage analysis using a threshold model

Ravindranath Duggirala, Jeff T. Williams, Sarah Williams-Blangero, John Blangero

    Research output: Contribution to journalArticlepeer-review

    150 Scopus citations

    Abstract

    We developed and utilized a multipoint variance components method to test for linkage between a disease trait and markers on chromosome 5 in the simulated data provided in GAW10 Problem 2. We demonstrated that the discrete trait variance components method recovers unbiased estimates of quantitative trait locus (QTL) location and reasonable estimates of effect size. We also showed that dichotomization of (a continuous trait such as) Q1 diminished the power to detect linkage compared to direct analysis of Q1, and that extended pedigree analyses provided superior power to detect linkage compared to those in nuclear families.

    Original languageEnglish (US)
    Pages (from-to)987-992
    Number of pages6
    JournalGenetic epidemiology
    Volume14
    Issue number6
    DOIs
    StatePublished - 1997

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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