A variance component approach to dichotomous trait linkage analysis using a threshold model

Ravindranath Duggirala, Jeff T. Williams, Sarah Williams-Blangero, John Blangero

Research output: Contribution to journalArticlepeer-review

151 Scopus citations

Abstract

We developed and utilized a multipoint variance components method to test for linkage between a disease trait and markers on chromosome 5 in the simulated data provided in GAW10 Problem 2. We demonstrated that the discrete trait variance components method recovers unbiased estimates of quantitative trait locus (QTL) location and reasonable estimates of effect size. We also showed that dichotomization of (a continuous trait such as) Q1 diminished the power to detect linkage compared to direct analysis of Q1, and that extended pedigree analyses provided superior power to detect linkage compared to those in nuclear families.

Original languageEnglish (US)
Pages (from-to)987-992
Number of pages6
JournalGenetic epidemiology
Volume14
Issue number6
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'A variance component approach to dichotomous trait linkage analysis using a threshold model'. Together they form a unique fingerprint.

Cite this