A transcriptional profile of the decidua in preeclampsia

Mari Løset, Siv B. Mundal, Matthew P. Johnson, Mona H. Fenstad, Katherine A. Freed, Ingrid A. Lian, Irina P. Eide, Line Bjørge, John Blangero, Eric K. Moses, Rigmor Austgulen

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

OBJECTIVE: We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis. STUDY DESIGN: Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies. Differentially expressed genes were identified and merged into canonical pathways and networks. RESULTS: Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P < .05; false discovery rate, P < .1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated (PLA2G7, HMOX1) genes were identified. Pathway analysis revealed that tryptophan metabolism, endoplasmic reticulum stress, linoleic acid metabolism, notch signaling, fatty acid metabolism, arachidonic acid metabolism, and NRF2-mediated oxidative stress response were overrepresented canonical pathways. CONCLUSION: In the present study single genes, canonical pathways, and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved.

Original languageEnglish (US)
Pages (from-to)84.e1-84.e27
JournalAmerican Journal of Obstetrics and Gynecology
Volume204
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

Keywords

  • decidua
  • genomewide gene expression
  • microarray
  • preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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