A transcriptional profile of the decidua in preeclampsia

Mari Løset, Siv B. Mundal, Matthew P. Johnson, Mona H. Fenstad, Katherine A. Freed, Ingrid A. Lian, Irina P. Eide, Line Bjørge, John Blangero, Eric K. Moses, Rigmor Austgulen

    Research output: Contribution to journalArticlepeer-review

    63 Scopus citations

    Abstract

    OBJECTIVE: We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis. STUDY DESIGN: Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies. Differentially expressed genes were identified and merged into canonical pathways and networks. RESULTS: Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P < .05; false discovery rate, P < .1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated (PLA2G7, HMOX1) genes were identified. Pathway analysis revealed that tryptophan metabolism, endoplasmic reticulum stress, linoleic acid metabolism, notch signaling, fatty acid metabolism, arachidonic acid metabolism, and NRF2-mediated oxidative stress response were overrepresented canonical pathways. CONCLUSION: In the present study single genes, canonical pathways, and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved.

    Original languageEnglish (US)
    Pages (from-to)84.e1-84.e27
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume204
    Issue number1
    DOIs
    StatePublished - Jan 2011

    Keywords

    • decidua
    • genomewide gene expression
    • microarray
    • preeclampsia

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

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