A tool to predict suicidal ideation and behavior in bipolar disorder

The Concise Health Risk Tracking Self-Report

Noreen A. Reilly-Harrington, Richard C. Shelton, Masoud Kamali, Dustin J. Rabideau, Leah W. Shesler, Madhukar H. Trivedi, Susan L. McElroy, Louisa G. Sylvia, Charles L. Bowden, Terence A. Ketter, Joseph R. Calabrese, Michael E. Thase, William V. Bobo, Thilo Deckersbach, Mauricio Tohen, Melvin G. McInnis, James H. Kocsis, Alexandra K. Gold, Vivek Singh, Daniel M. Finkelstein & 2 others Gustavo Kinrys, Andrew A. Nierenberg

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Few brief, self-report measures exist that can reliably predict adverse suicidality outcomes in patients with BD. This study utilized the Concise Health Risk Tracking Self-Report (CHRT) to assess suicidality in patients with BD and examined its psychometric performance, clinical correlates, and prospective value in predicting adverse events related to suicidality. Methods The CHRT was administered at baseline and follow-up to 482 adult patients in Bipolar CHOICE, a 6-month randomized comparative effectiveness trial. The Columbia Suicide Severity Rating Scale (CSSRS) was used at baseline to assess lifetime history of suicide attempts and related behaviors. Clinician-rated measures of mood (Bipolar Inventory of Symptoms Scale) and bipolar symptoms (Clinical Global Impressions-Bipolar Version) were conducted at baseline and follow-up. Results The CHRT showed excellent internal consistency and construct validity and was highly correlated with clinician ratings of depression, anxiety, and overall functioning at baseline and throughout the study. Baseline CHRT scores significantly predicted risk of subsequent suicidality-related Serious Adverse Events (sSAEs), after controlling for mood and comorbidity. Specifically, the hazard of a sSAE increased by 76% for every 10-point increase in baseline CHRT score. Past history of suicide attempts and related behaviors, as assessed by the CSSRS, did not predict subsequent sSAEs. Limitations The CSSRS was used to assess static risk factors in terms of past suicidal behaviors and may have been a more powerful predictor over longer-term follow-up. Conclusions The CHRT offers a quick and robust self-report tool for assessing suicidal risk and has important implications for future research and clinical practice.

Original languageEnglish (US)
Pages (from-to)212-218
Number of pages7
JournalJournal of Affective Disorders
Volume192
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Fingerprint

Suicidal Ideation
Bipolar Disorder
Self Report
Suicide
Health
Psychometrics
Comorbidity
Anxiety
Depression
Equipment and Supplies

Keywords

  • Bipolar disorder
  • Psychometrics
  • Risk
  • Self-report
  • Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Reilly-Harrington, N. A., Shelton, R. C., Kamali, M., Rabideau, D. J., Shesler, L. W., Trivedi, M. H., ... Nierenberg, A. A. (2016). A tool to predict suicidal ideation and behavior in bipolar disorder: The Concise Health Risk Tracking Self-Report. Journal of Affective Disorders, 192, 212-218. https://doi.org/10.1016/j.jad.2015.12.036

A tool to predict suicidal ideation and behavior in bipolar disorder : The Concise Health Risk Tracking Self-Report. / Reilly-Harrington, Noreen A.; Shelton, Richard C.; Kamali, Masoud; Rabideau, Dustin J.; Shesler, Leah W.; Trivedi, Madhukar H.; McElroy, Susan L.; Sylvia, Louisa G.; Bowden, Charles L.; Ketter, Terence A.; Calabrese, Joseph R.; Thase, Michael E.; Bobo, William V.; Deckersbach, Thilo; Tohen, Mauricio; McInnis, Melvin G.; Kocsis, James H.; Gold, Alexandra K.; Singh, Vivek; Finkelstein, Daniel M.; Kinrys, Gustavo; Nierenberg, Andrew A.

In: Journal of Affective Disorders, Vol. 192, 01.03.2016, p. 212-218.

Research output: Contribution to journalArticle

Reilly-Harrington, NA, Shelton, RC, Kamali, M, Rabideau, DJ, Shesler, LW, Trivedi, MH, McElroy, SL, Sylvia, LG, Bowden, CL, Ketter, TA, Calabrese, JR, Thase, ME, Bobo, WV, Deckersbach, T, Tohen, M, McInnis, MG, Kocsis, JH, Gold, AK, Singh, V, Finkelstein, DM, Kinrys, G & Nierenberg, AA 2016, 'A tool to predict suicidal ideation and behavior in bipolar disorder: The Concise Health Risk Tracking Self-Report', Journal of Affective Disorders, vol. 192, pp. 212-218. https://doi.org/10.1016/j.jad.2015.12.036
Reilly-Harrington, Noreen A. ; Shelton, Richard C. ; Kamali, Masoud ; Rabideau, Dustin J. ; Shesler, Leah W. ; Trivedi, Madhukar H. ; McElroy, Susan L. ; Sylvia, Louisa G. ; Bowden, Charles L. ; Ketter, Terence A. ; Calabrese, Joseph R. ; Thase, Michael E. ; Bobo, William V. ; Deckersbach, Thilo ; Tohen, Mauricio ; McInnis, Melvin G. ; Kocsis, James H. ; Gold, Alexandra K. ; Singh, Vivek ; Finkelstein, Daniel M. ; Kinrys, Gustavo ; Nierenberg, Andrew A. / A tool to predict suicidal ideation and behavior in bipolar disorder : The Concise Health Risk Tracking Self-Report. In: Journal of Affective Disorders. 2016 ; Vol. 192. pp. 212-218.
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abstract = "Background Few brief, self-report measures exist that can reliably predict adverse suicidality outcomes in patients with BD. This study utilized the Concise Health Risk Tracking Self-Report (CHRT) to assess suicidality in patients with BD and examined its psychometric performance, clinical correlates, and prospective value in predicting adverse events related to suicidality. Methods The CHRT was administered at baseline and follow-up to 482 adult patients in Bipolar CHOICE, a 6-month randomized comparative effectiveness trial. The Columbia Suicide Severity Rating Scale (CSSRS) was used at baseline to assess lifetime history of suicide attempts and related behaviors. Clinician-rated measures of mood (Bipolar Inventory of Symptoms Scale) and bipolar symptoms (Clinical Global Impressions-Bipolar Version) were conducted at baseline and follow-up. Results The CHRT showed excellent internal consistency and construct validity and was highly correlated with clinician ratings of depression, anxiety, and overall functioning at baseline and throughout the study. Baseline CHRT scores significantly predicted risk of subsequent suicidality-related Serious Adverse Events (sSAEs), after controlling for mood and comorbidity. Specifically, the hazard of a sSAE increased by 76{\%} for every 10-point increase in baseline CHRT score. Past history of suicide attempts and related behaviors, as assessed by the CSSRS, did not predict subsequent sSAEs. Limitations The CSSRS was used to assess static risk factors in terms of past suicidal behaviors and may have been a more powerful predictor over longer-term follow-up. Conclusions The CHRT offers a quick and robust self-report tool for assessing suicidal risk and has important implications for future research and clinical practice.",
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T1 - A tool to predict suicidal ideation and behavior in bipolar disorder

T2 - The Concise Health Risk Tracking Self-Report

AU - Reilly-Harrington, Noreen A.

AU - Shelton, Richard C.

AU - Kamali, Masoud

AU - Rabideau, Dustin J.

AU - Shesler, Leah W.

AU - Trivedi, Madhukar H.

AU - McElroy, Susan L.

AU - Sylvia, Louisa G.

AU - Bowden, Charles L.

AU - Ketter, Terence A.

AU - Calabrese, Joseph R.

AU - Thase, Michael E.

AU - Bobo, William V.

AU - Deckersbach, Thilo

AU - Tohen, Mauricio

AU - McInnis, Melvin G.

AU - Kocsis, James H.

AU - Gold, Alexandra K.

AU - Singh, Vivek

AU - Finkelstein, Daniel M.

AU - Kinrys, Gustavo

AU - Nierenberg, Andrew A.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background Few brief, self-report measures exist that can reliably predict adverse suicidality outcomes in patients with BD. This study utilized the Concise Health Risk Tracking Self-Report (CHRT) to assess suicidality in patients with BD and examined its psychometric performance, clinical correlates, and prospective value in predicting adverse events related to suicidality. Methods The CHRT was administered at baseline and follow-up to 482 adult patients in Bipolar CHOICE, a 6-month randomized comparative effectiveness trial. The Columbia Suicide Severity Rating Scale (CSSRS) was used at baseline to assess lifetime history of suicide attempts and related behaviors. Clinician-rated measures of mood (Bipolar Inventory of Symptoms Scale) and bipolar symptoms (Clinical Global Impressions-Bipolar Version) were conducted at baseline and follow-up. Results The CHRT showed excellent internal consistency and construct validity and was highly correlated with clinician ratings of depression, anxiety, and overall functioning at baseline and throughout the study. Baseline CHRT scores significantly predicted risk of subsequent suicidality-related Serious Adverse Events (sSAEs), after controlling for mood and comorbidity. Specifically, the hazard of a sSAE increased by 76% for every 10-point increase in baseline CHRT score. Past history of suicide attempts and related behaviors, as assessed by the CSSRS, did not predict subsequent sSAEs. Limitations The CSSRS was used to assess static risk factors in terms of past suicidal behaviors and may have been a more powerful predictor over longer-term follow-up. Conclusions The CHRT offers a quick and robust self-report tool for assessing suicidal risk and has important implications for future research and clinical practice.

AB - Background Few brief, self-report measures exist that can reliably predict adverse suicidality outcomes in patients with BD. This study utilized the Concise Health Risk Tracking Self-Report (CHRT) to assess suicidality in patients with BD and examined its psychometric performance, clinical correlates, and prospective value in predicting adverse events related to suicidality. Methods The CHRT was administered at baseline and follow-up to 482 adult patients in Bipolar CHOICE, a 6-month randomized comparative effectiveness trial. The Columbia Suicide Severity Rating Scale (CSSRS) was used at baseline to assess lifetime history of suicide attempts and related behaviors. Clinician-rated measures of mood (Bipolar Inventory of Symptoms Scale) and bipolar symptoms (Clinical Global Impressions-Bipolar Version) were conducted at baseline and follow-up. Results The CHRT showed excellent internal consistency and construct validity and was highly correlated with clinician ratings of depression, anxiety, and overall functioning at baseline and throughout the study. Baseline CHRT scores significantly predicted risk of subsequent suicidality-related Serious Adverse Events (sSAEs), after controlling for mood and comorbidity. Specifically, the hazard of a sSAE increased by 76% for every 10-point increase in baseline CHRT score. Past history of suicide attempts and related behaviors, as assessed by the CSSRS, did not predict subsequent sSAEs. Limitations The CSSRS was used to assess static risk factors in terms of past suicidal behaviors and may have been a more powerful predictor over longer-term follow-up. Conclusions The CHRT offers a quick and robust self-report tool for assessing suicidal risk and has important implications for future research and clinical practice.

KW - Bipolar disorder

KW - Psychometrics

KW - Risk

KW - Self-report

KW - Suicide

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