A tail withdrawal procedure for assessing analgesic activity in rhesus monkeys

Linda A. Dykstra, James H. Woods

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Rhesus monkeys were restrained in chairs from which their tails hung free so that their tails could be immersed into a thermos of water. Monkeys consistently kept their tails in 38-40°C water for at least 20 sec, but withdrew them from 55°C water in 1-4 sec. Tail withdrawal latencies from 55°C water remained consistent over a period of 3 hr. Morphine produced dose-dependent increases in tail withdrawal latencies from 55°C water, whereas pentobarbital, haloperidol, and phencyclidine did not increase tail withdrawal latencies except at doses that produced marked sedation.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalJournal of Pharmacological Methods
Volume15
Issue number3
DOIs
StatePublished - Jun 1986
Externally publishedYes

Keywords

  • Analgesia
  • Morphine
  • Rhesus monkeys
  • Tail withdrawal

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'A tail withdrawal procedure for assessing analgesic activity in rhesus monkeys'. Together they form a unique fingerprint.

  • Cite this