A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies

Alexandre Chan, Michael C. Cameron, Benjamin Garden, Christine B. Boers-Doets, Katja Schindler, Joel B. Epstein, Jennifer Choi, Laura Beamer, Eric Roeland, Elvio G. Russi, René Jean Bensadoun, Yi Ling Teo, Raymond J. Chan, Vivianne Shih, Jane Bryce, Judith Raber-Durlacher, Peter Arne Gerber, César O. Freytes, Bernardo Rapoport, Nicole LeBoeufVincent Sibaud, Mario E. Lacouture

Research output: Contribution to journalArticle

13 Scopus citations


Purpose: Dermatologic adverse events (dAEs) in cancer treatment are frequent with the use of targeted therapies. These dAEs have been shown to have significant impact on health-related quality of life (HRQoL). While standardized assessment tools have been developed for physicians to assess severity of dAEs, there is a discord between objective and subjective measures. The identification of patient-reported outcome (PRO) instruments useful in the context of targeted cancer therapies is therefore important in both the clinical and research settings for the overall evaluation of dAEs and their impact on HRQoL. Methods: A comprehensive, systematic literature search of published articles was conducted by two independent reviewers in order to identify PRO instruments previously utilized in patient populations with dAEs from targeted cancer therapies. The identified PRO instruments were studied to determine which HRQoL issues relevant to dAEs were addressed, as well as the process of development and validation of these instruments. Results: Thirteen articles identifying six PRO instruments met the inclusion criteria. Four instruments were general dermatology (Skindex-16

Original languageEnglish (US)
Pages (from-to)2231-2244
Number of pages14
JournalSupportive Care in Cancer
Issue number8
StatePublished - Aug 29 2015



  • Dermatologic adverse events
  • Health-related quality of life
  • Patient-reported outcomes
  • Targeted cancer therapy

ASJC Scopus subject areas

  • Oncology

Cite this

Chan, A., Cameron, M. C., Garden, B., Boers-Doets, C. B., Schindler, K., Epstein, J. B., Choi, J., Beamer, L., Roeland, E., Russi, E. G., Bensadoun, R. J., Teo, Y. L., Chan, R. J., Shih, V., Bryce, J., Raber-Durlacher, J., Gerber, P. A., Freytes, C. O., Rapoport, B., ... Lacouture, M. E. (2015). A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies. Supportive Care in Cancer, 23(8), 2231-2244. https://doi.org/10.1007/s00520-014-2564-x