A subpopulation of cultured avian neural crest cells has transient neurogenic potential

Kristine S. Vogel, James A. Weston

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Neural crest cells of vertebrate embryos produce neurons, glia, pigment cells, and connective tissue in vivo and in vitro. To test the developmental potential of apparently undifferentiated crest cells, we have used the monoclonal antibody A2B5, which recognizes a cell surface glycolipid characteristic of neurons, to identify and immunoablate a subpopulation of cultured avian neural crest cells with a neuronal phenotype. Our results indicate that a limited neurogenic precursor subpopulation is present in cultures of avian neural crest cells and that the fate of this subpopulation can be influenced by environmental conditions arising when dispersal of neural crest cells is delayed.

Original languageEnglish (US)
Pages (from-to)569-577
Number of pages9
JournalNeuron
Volume1
Issue number7
DOIs
StatePublished - Sep 1988
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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