A STUDY OF THE INCREASED SERUM LEVEL OF IgG1 IN ‘LETHARGIC’ MICE COMBINED WITH A DEPRESSED THYMUS‐DEPENDENT LYMPHOID SYSTEM

H. C. Dung, R. L. Lawson, M. Stevens, Gail A. Walker

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In a series of recent studies on ‘lethargic’ mice, a neurological mutation of the mouse, significant abnormalities were discovered in the thymus and its dependent regions in the lymph nodes and spleen. The present study was made as an approach toward finding the possible causes for these abnormalities. Serum IgG1 levels were studied in ‘lethargic’ mutants at the age when severe deficiency of the thymus‐dependent lymphoid system is known to occur in the animal. Using the radial immunodiffusion method, it was found that serum IgG1 levels are always significantly higher in ‘lethargic’ mice than in their normal littermates. Possible causes of the higher IgG1 in the serum of ‘lethargic’ mice are discussed. The authors note the similarities of other mouse mutations to that of the ‘lethargic’ mouse and propose the possibility that a common mechanism may account for immunologic deficiencies in several types of mutant mice.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalInternational Journal of Immunogenetics
Volume4
Issue number4
DOIs
StatePublished - Aug 1977

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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