A study of indoles which inhibit pineal antigonadotrophic activity in Male hamsters

Russel J. Reiter; Mary K. Vaughan

doi:10.3109/07435807509053856

A study of indoles which inhibit pineal antigonadotrophic activity in Male hamsters

Russel J. Reiter, Mary K. Vaughan

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Blinding adult male golden hamsters led to involution of the testes and accessory sex organs (seminal vesicles and coagulating glands) and to a regression in pituitary prolactin levels within 8 weeks. The subcutaneous implantation of either melatonin or 6-hydroxymelatonin (1 mg/wk in beeswax) prevented the atrophy of the reproductive organs and the decrease in the stores of pituitary prolactin. Two other indoles, N-acetylserotonin and 5-hydroxytryptophol, failed to counteract the reproductive effects of blinding. Both melatonin and 6-hydroxymelatonin significantly elevated plasma LH titers.

Original language	English (US)
Pages (from-to)	299-308
Number of pages	10
Journal	Endocrine Research
Volume	2
Issue number	3
DOIs	https://doi.org/10.3109/07435807509053856
State	Published - 1975

ASJC Scopus subject areas

Endocrinology

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title = "A study of indoles which inhibit pineal antigonadotrophic activity in Male hamsters",

abstract = "Blinding adult male golden hamsters led to involution of the testes and accessory sex organs (seminal vesicles and coagulating glands) and to a regression in pituitary prolactin levels within 8 weeks. The subcutaneous implantation of either melatonin or 6-hydroxymelatonin (1 mg/wk in beeswax) prevented the atrophy of the reproductive organs and the decrease in the stores of pituitary prolactin. Two other indoles, N-acetylserotonin and 5-hydroxytryptophol, failed to counteract the reproductive effects of blinding. Both melatonin and 6-hydroxymelatonin significantly elevated plasma LH titers.",

author = "Reiter, {Russel J.} and Vaughan, {Mary K.}",

note = "Funding Information: Supported in part by NSF grant CB-43233X and by a grant from the Population Council, M74.87. Russel J. Reiter is a U. S. P. H. S. Career Development Awardee, HD-42398. Mary K. Vaughan is a U. S. P. H. S. Postdoctoral Fellow, AM-55966.",

year = "1975",

doi = "10.3109/07435807509053856",

language = "English (US)",

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journal = "Endocrine Research",

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T1 - A study of indoles which inhibit pineal antigonadotrophic activity in Male hamsters

AU - Reiter, Russel J.

AU - Vaughan, Mary K.

N1 - Funding Information: Supported in part by NSF grant CB-43233X and by a grant from the Population Council, M74.87. Russel J. Reiter is a U. S. P. H. S. Career Development Awardee, HD-42398. Mary K. Vaughan is a U. S. P. H. S. Postdoctoral Fellow, AM-55966.

PY - 1975

Y1 - 1975

N2 - Blinding adult male golden hamsters led to involution of the testes and accessory sex organs (seminal vesicles and coagulating glands) and to a regression in pituitary prolactin levels within 8 weeks. The subcutaneous implantation of either melatonin or 6-hydroxymelatonin (1 mg/wk in beeswax) prevented the atrophy of the reproductive organs and the decrease in the stores of pituitary prolactin. Two other indoles, N-acetylserotonin and 5-hydroxytryptophol, failed to counteract the reproductive effects of blinding. Both melatonin and 6-hydroxymelatonin significantly elevated plasma LH titers.

AB - Blinding adult male golden hamsters led to involution of the testes and accessory sex organs (seminal vesicles and coagulating glands) and to a regression in pituitary prolactin levels within 8 weeks. The subcutaneous implantation of either melatonin or 6-hydroxymelatonin (1 mg/wk in beeswax) prevented the atrophy of the reproductive organs and the decrease in the stores of pituitary prolactin. Two other indoles, N-acetylserotonin and 5-hydroxytryptophol, failed to counteract the reproductive effects of blinding. Both melatonin and 6-hydroxymelatonin significantly elevated plasma LH titers.

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A study of indoles which inhibit pineal antigonadotrophic activity in Male hamsters

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