A study of indoles which inhibit pineal antigonadotrophic activity in Male hamsters

Russel J. Reiter, Mary K. Vaughan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Blinding adult male golden hamsters led to involution of the testes and accessory sex organs (seminal vesicles and coagulating glands) and to a regression in pituitary prolactin levels within 8 weeks. The subcutaneous implantation of either melatonin or 6-hydroxymelatonin (1 mg/wk in beeswax) prevented the atrophy of the reproductive organs and the decrease in the stores of pituitary prolactin. Two other indoles, N-acetylserotonin and 5-hydroxytryptophol, failed to counteract the reproductive effects of blinding. Both melatonin and 6-hydroxymelatonin significantly elevated plasma LH titers.

Original languageEnglish (US)
Pages (from-to)299-308
Number of pages10
JournalEndocrine Research
Volume2
Issue number3
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Endocrinology

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