Abstract
Blinding adult male golden hamsters led to involution of the testes and accessory sex organs (seminal vesicles and coagulating glands) and to a regression in pituitary prolactin levels within 8 weeks. The subcutaneous implantation of either melatonin or 6-hydroxymelatonin (1 mg/wk in beeswax) prevented the atrophy of the reproductive organs and the decrease in the stores of pituitary prolactin. Two other indoles, N-acetylserotonin and 5-hydroxytryptophol, failed to counteract the reproductive effects of blinding. Both melatonin and 6-hydroxymelatonin significantly elevated plasma LH titers.
Original language | English (US) |
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Pages (from-to) | 299-308 |
Number of pages | 10 |
Journal | Endocrine Research |
Volume | 2 |
Issue number | 3 |
DOIs | |
State | Published - 1975 |
ASJC Scopus subject areas
- Endocrinology