A stage-specific inhibitory effect of benzamil on Xenopus oocyte maturation located at the cell surface

Ivan L. Cameron, Keithley E. Hunter, Edward J. Cragoe

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Benzamil, a drug reported to block passive Na+ transport, also inhibits progesterone-induced maturation of Xenopus oocytes when given early in the maturation period. The localization of tritiated benzamil at the oocyte surface was verified by autoradiography using a method that prevents diffusion of substances. These data indicate that the primary site of action of benzamil is at the cell surface.

Original languageEnglish (US)
Pages (from-to)455-457
Number of pages3
JournalExperimental Cell Research
Volume139
Issue number2
DOIs
StatePublished - Jun 1982
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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