A simple photo-affinity labeling protocol

Hong Yu Li, Ying Liu, Kan Fang, Koji Nakanishi

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


After photo-crosslinking and proteolysis of a photoaffinity labeled ligand to its receptor, the ester group incorporated in the ligand is cleaved by an amine with specific functionality, which displaces the bulk of the ligand from the peptide fragments, and facilitates subsequent tandem mass spectrometric sequencing.

Original languageEnglish (US)
Pages (from-to)365-366
Number of pages2
JournalChemical Communications
Issue number4
StatePublished - Feb 21 1999
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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