TY - JOUR
T1 - A Secular Increase in Child and Adolescent Onset Affective Disorder
AU - RYAN, NEAL D.
AU - WILLIAMSON, DOUGLAS E.
AU - IYENGAR, SATISH
AU - ORVASCHEL, HELEN
AU - REICH, THEODORE
AU - DAHL, RONALD E.
AU - PUIG-ANTICH, JOAQUIM
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Both longitudinal and cross-sectional studies utilizing population and family study samples have found evidence for a secular increase in major affective disorders in adults. Applying techniques used in cross-sectional studies in adults to family study data of children and adolescents, the authors demonstrate evidence of a parallel secular increase for child and adolescent onset affective disorders. Normal and depressed prepubertal probands were identified. All full siblings were directly interviewed for lifetime episodes of affective disorder. Analysis of the siblings (probands not further analyzed in this article) by the Cox proportional hazards model demonstrates that the risk for affective disorder is higher in siblings born more recently.
AB - Both longitudinal and cross-sectional studies utilizing population and family study samples have found evidence for a secular increase in major affective disorders in adults. Applying techniques used in cross-sectional studies in adults to family study data of children and adolescents, the authors demonstrate evidence of a parallel secular increase for child and adolescent onset affective disorders. Normal and depressed prepubertal probands were identified. All full siblings were directly interviewed for lifetime episodes of affective disorder. Analysis of the siblings (probands not further analyzed in this article) by the Cox proportional hazards model demonstrates that the risk for affective disorder is higher in siblings born more recently.
KW - child and adolescent affective disorders
KW - proportional hazards
KW - secular increase
UR - http://www.scopus.com/inward/record.url?scp=0026740231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026740231&partnerID=8YFLogxK
U2 - 10.1097/00004583-199207000-00004
DO - 10.1097/00004583-199207000-00004
M3 - Article
C2 - 1644720
AN - SCOPUS:0026740231
VL - 31
SP - 600
EP - 605
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
SN - 0890-8567
IS - 4
ER -