A screen for mutations that suppress the phenotype of Drosophila armadillo, the β-catenin homolog

Rachel T. Cox, Donald G. McEwen, Denise L. Myster, Robert J. Duronio, Joseph Loureiro, Mark Peifer

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


During development signaling pathways coordinate cell fates and regulate the choice between cell survival or programmed cell death. The well-conserved Wingless/Wnt pathway is required for many developmental decisions in all animals. One transducer of the Wingless/Wnt signal is Armadillo/β-catenin. Drosophila Armadillo not only transduces Wingless signal, but also acts in cell-cell adhesion via its role in the epithelial adherens junction. While many components of both the Wingless/Wnt signaling pathway and adherens junctions are known, both processes are complex, suggesting that unknown components influence signaling and junctions. We carried out a genetic modifier screen to identify some of these components by screening for mutations that can suppress the armadillo mutant phenotype. We identified 12 regions of the genome that have this property. From these regions and from additional candidate genes tested we identified four genes that suppress arm: dTCF, puckered, head involution defective (hid), and Dpresenilin. We further investigated the interaction with hid, a known regulator of programmed cell death. Our data suggest that Wg signaling modulates Hid activity and that Hid regulates programmed cell death in a dose-sensitive fashion.

Original languageEnglish (US)
Pages (from-to)1725-1740
Number of pages16
Issue number4
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


Dive into the research topics of 'A screen for mutations that suppress the phenotype of Drosophila armadillo, the β-catenin homolog'. Together they form a unique fingerprint.

Cite this