A role of the rostral hypothalamus in the regulation of LHRH release in baboons

N. Hagino

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In the intact control baboons the plasma level of LH was elevated and reached a peak within 15 minutes after administration of 100 μg synthetic LHRH. In addition, a second peak in plasma LH appeared within 90 minutes after LHRH injection. Supplementing these results, plasma level of estrogen was elevated within 30 minutes after LHRH injection. Subsequently, frontal deafferentation of the hypothalamus was performed in these baboons. After administration of 100 μg synthetic LHRH in these frontally deafferented baboons the plasma level of LH was elevated and reached a peak within 15 minutes, as in the intact control baboons. However, there was no second LH peak within 90 minutes after LHRH injection, even though plasma estrogen was elevated within 30 minutes, as in the intact control baboons. It was found that the rostral hypothalamus in baboons is involved in the regulation of LHRH release which promotes to release LH within 90 minutes after LHRH injection.

Original languageEnglish (US)
Pages (from-to)150-154
Number of pages5
JournalHormone and Metabolic Research
Volume12
Issue number4
DOIs
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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