A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection

D. M. Williams, B. G. Grubbs, T. Darville, K. Kelly, R. G. Rank

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Interleukin-6-deficient (IL-6(-/-)) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after intranasal infection. Gamma interferon production and chlamydia-specific antibody levels were consistent with a decreased but reversible Th1-like response in IL-6(-/-) mice. IL-6 is needed for an optimal early host response to this infection.

Original languageEnglish (US)
Pages (from-to)4564-4567
Number of pages4
JournalInfection and immunity
Volume66
Issue number9
DOIs
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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