A role for IL-1α in inducing pathologic inflammation during bacterial infection

Peter H Dube, Paula A. Revell, David D. Chaplin, Robin G. Lorenz, Virginia L. Miller

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Infection with pathogenic microbes often results in a significant inflammatory response. A cascade of proinflammatory cytokines including tumor necrosis factor α (TNF-α) and IL-1 initiates this response. Although there is a clear role for IL-1 during infection, little is known to distinguish the role of IL-1α from that of IL-1β during this process. With the use of Yersinia enterocolitica as a model enteric pathogen, we have identified a specific role for IL-1α in inducing pathologic inflammation during bacterial infection. Depletion of IL-1α in mice infected with wild-type Y. enterocolitica results in significantly decreased intestinal inflammation. Furthermore, a bacterial mutant that does not induce IL-1α expression but induces normal levels of IL-1β, TNF-α, and IFN-γ, causes greatly reduced intestinal inflammation and is attenuated by LD50 analysis in the C57BL/6 mouse model. These results demonstrate a distinct and unrecognized role for IL-1α in inducing intestinal inflammation that cannot be compensated for by the endogenous levels of IL-1β, TNF-α, or IFN-γ that are produced in response to Y. enterocolitica. Additionally, these results suggest that IL-1α-induced inflammation is a major contributor to the pathology of yersiniosis.

Original languageEnglish (US)
Pages (from-to)10880-10885
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number19
DOIs
StatePublished - Sep 11 2001
Externally publishedYes

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Interleukin-1
Bacterial Infections
Inflammation
Yersinia enterocolitica
Tumor Necrosis Factor-alpha
Lethal Dose 50
Infection
Inbred C57BL Mouse
Pathology
Cytokines

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

A role for IL-1α in inducing pathologic inflammation during bacterial infection. / Dube, Peter H; Revell, Paula A.; Chaplin, David D.; Lorenz, Robin G.; Miller, Virginia L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 19, 11.09.2001, p. 10880-10885.

Research output: Contribution to journalArticle

Dube, Peter H ; Revell, Paula A. ; Chaplin, David D. ; Lorenz, Robin G. ; Miller, Virginia L. / A role for IL-1α in inducing pathologic inflammation during bacterial infection. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 19. pp. 10880-10885.
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