A revised estimate of twin concordance in systemic lupus erythematosus

Dennis Deafen, Agustin Escalante, Lisa Weinrib, David Horwitz, Barbara Bachman, Pradip Roy‐Burman, Ann Walker, Thomas M. Mack

Research output: Contribution to journalArticle

563 Scopus citations

Abstract

Objective. Based on a small clinical series and previously published case reports, concordance for systemic lupus erythematosus (SLE) among monozygous (MZ) twins has been reported to be as high as 69%. Using a larger and less biased sample, we provide another estimate of this percentage. Methods. We established a registry of twins with SLE, based upon self‐reports and information provided by the patients' physicians. We used DNA fingerprinting to validate the reported zygosity in a sample of these twins. Results. Of 107 twin pairs meeting the American College of Rheumatology 1982 revised criteria for the diagnosis of SLE, 24% of 45 MZ pairs and 2% of 62 dizygous (DZ) pairs were concordant. The frequency distributions of diagnostic criteria and disease symptoms in the SLE patients were similar to those in other published reports of SLE patients. Zygosity was confirmed by DNA fingerprinting in a subsample of 15 self‐described MZ twins and 7 self‐described DZ twins. AH individuals had correctly predicted their zygosity. Conclusion. MZ concordance for SLE is similar to that for other autoimmune diseases and is much lower than previously believed.

Original languageEnglish (US)
Pages (from-to)311-318
Number of pages8
JournalArthritis & Rheumatism
Volume35
Issue number3
DOIs
StatePublished - Mar 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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    Deafen, D., Escalante, A., Weinrib, L., Horwitz, D., Bachman, B., Roy‐Burman, P., Walker, A., & Mack, T. M. (1992). A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis & Rheumatism, 35(3), 311-318. https://doi.org/10.1002/art.1780350310