A review on the wettability of dental implant surfaces II: Biological and clinical aspects

Rolando A. Gittens, Lutz Scheideler, Frank Rupp, Sharon L. Hyzy, Jürgen Geis-Gerstorfer, Zvi Schwartz, Barbara D. Boyan

Research output: Contribution to journalReview articlepeer-review

382 Scopus citations


Dental and orthopedic implants have been under continuous advancement to improve their interactions with bone and ensure a successful outcome for patients. Surface characteristics such as surface topography and surface chemistry can serve as design tools to enhance the biological response around the implant, with in vitro, in vivo and clinical studies confirming their effects. However, the comprehensive design of implants to promote early and long-term osseointegration requires a better understanding of the role of surface wettability and the mechanisms by which it affects the surrounding biological environment. This review provides a general overview of the available information about the contact angle values of experimental and of marketed implant surfaces, some of the techniques used to modify surface wettability of implants, and results from in vitro and clinical studies. We aim to expand the current understanding on the role of wettability of metallic implants at their interface with blood and the biological milieu, as well as with bacteria, and hard and soft tissues.

Original languageEnglish (US)
Pages (from-to)2907-2918
Number of pages12
JournalActa Biomaterialia
Issue number7
StatePublished - Jul 2014


  • Hydrophilicity
  • Osseointegration
  • Surface conditioning
  • Surface energy
  • Titanium implant roughness

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology


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