A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications

Maribel I. Baker, Steven P. Walsh, Zvi Schwartz, Barbara D. Boyan

Research output: Contribution to journalReview articlepeer-review

747 Scopus citations


Polyvinyl alcohol (PVA) is a synthetic polymer derived from polyvinyl acetate through partial or full hydroxylation. PVA is commonly used in medical devices due to its low protein adsorption characteristics, biocompatibility, high water solubility, and chemical resistance. Some of the most common medical uses of PVA are in soft contact lenses, eye drops, embolization particles, tissue adhesion barriers, and as artificial cartilage and meniscus. The purpose of this review is to evaluate the available published information on PVA with respect to its safety as a medical device implant material for cartilage replacement. The review includes historical clinical use of PVA in orthopedics, and in vitro and in vivo biocompatibility studies. Finally, the safety recommendation involving the further development of PVA cryogels for cartilage replacement is addressed.

Original languageEnglish (US)
Pages (from-to)1451-1457
Number of pages7
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume100 B
Issue number5
StatePublished - Jul 2012


  • Cartilage replacement
  • Hydrogels
  • Polymer
  • Polyvinyl alcohol

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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