A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications

Maribel I. Baker; Steven P. Walsh; Zvi Schwartz; Barbara D. Boyan

doi:10.1002/jbm.b.32694

A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications

Maribel I. Baker, Steven P. Walsh, Zvi Schwartz, Barbara D. Boyan

Department of Periodontics

Research output: Contribution to journal › Review article › peer-review

747 Scopus citations

Abstract

Polyvinyl alcohol (PVA) is a synthetic polymer derived from polyvinyl acetate through partial or full hydroxylation. PVA is commonly used in medical devices due to its low protein adsorption characteristics, biocompatibility, high water solubility, and chemical resistance. Some of the most common medical uses of PVA are in soft contact lenses, eye drops, embolization particles, tissue adhesion barriers, and as artificial cartilage and meniscus. The purpose of this review is to evaluate the available published information on PVA with respect to its safety as a medical device implant material for cartilage replacement. The review includes historical clinical use of PVA in orthopedics, and in vitro and in vivo biocompatibility studies. Finally, the safety recommendation involving the further development of PVA cryogels for cartilage replacement is addressed.

Original language	English (US)
Pages (from-to)	1451-1457
Number of pages	7
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	100 B
Issue number	5
DOIs	https://doi.org/10.1002/jbm.b.32694
State	Published - Jul 2012

Keywords

Cartilage replacement
Hydrogels
Polymer
Polyvinyl alcohol

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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10.1002/jbm.b.32694

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title = "A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications",

abstract = "Polyvinyl alcohol (PVA) is a synthetic polymer derived from polyvinyl acetate through partial or full hydroxylation. PVA is commonly used in medical devices due to its low protein adsorption characteristics, biocompatibility, high water solubility, and chemical resistance. Some of the most common medical uses of PVA are in soft contact lenses, eye drops, embolization particles, tissue adhesion barriers, and as artificial cartilage and meniscus. The purpose of this review is to evaluate the available published information on PVA with respect to its safety as a medical device implant material for cartilage replacement. The review includes historical clinical use of PVA in orthopedics, and in vitro and in vivo biocompatibility studies. Finally, the safety recommendation involving the further development of PVA cryogels for cartilage replacement is addressed.",

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AU - Baker, Maribel I.

AU - Walsh, Steven P.

AU - Schwartz, Zvi

AU - Boyan, Barbara D.

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N2 - Polyvinyl alcohol (PVA) is a synthetic polymer derived from polyvinyl acetate through partial or full hydroxylation. PVA is commonly used in medical devices due to its low protein adsorption characteristics, biocompatibility, high water solubility, and chemical resistance. Some of the most common medical uses of PVA are in soft contact lenses, eye drops, embolization particles, tissue adhesion barriers, and as artificial cartilage and meniscus. The purpose of this review is to evaluate the available published information on PVA with respect to its safety as a medical device implant material for cartilage replacement. The review includes historical clinical use of PVA in orthopedics, and in vitro and in vivo biocompatibility studies. Finally, the safety recommendation involving the further development of PVA cryogels for cartilage replacement is addressed.

AB - Polyvinyl alcohol (PVA) is a synthetic polymer derived from polyvinyl acetate through partial or full hydroxylation. PVA is commonly used in medical devices due to its low protein adsorption characteristics, biocompatibility, high water solubility, and chemical resistance. Some of the most common medical uses of PVA are in soft contact lenses, eye drops, embolization particles, tissue adhesion barriers, and as artificial cartilage and meniscus. The purpose of this review is to evaluate the available published information on PVA with respect to its safety as a medical device implant material for cartilage replacement. The review includes historical clinical use of PVA in orthopedics, and in vitro and in vivo biocompatibility studies. Finally, the safety recommendation involving the further development of PVA cryogels for cartilage replacement is addressed.

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KW - Polymer

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A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications

Abstract

Keywords

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