A review of NMDA receptors and the phencyclidine model of schizophrenia

Sheri A. Thornberg, Stephen R. Saklad

    Research output: Contribution to journalReview articlepeer-review

    62 Scopus citations

    Abstract

    Current models of drug-induced psychosis insufficiently describe the symptoms of schizophrenia. Phencyclidine-induced psychosis is a model that more completely reflects the pathophysiology of the disease. By decreasing glutamatergic neurotransmission, phencyclidine decreases γ-aminobutyric acid release from the nucleus accumbens, striatum, and hippocampus (manifested by MK-801); may inhibit tonic release of dopamine from the nucleus accumbens and striatum, resulting in increased dopamine phasic reactivity; and decreases long-term potentiation. Glutamatergic system dysfunction may be involved, but pharmacologic manipulation has not revealed a clear mechanism of this dysfunction.

    Original languageEnglish (US)
    Pages (from-to)82-93
    Number of pages12
    JournalPharmacotherapy
    Volume16
    Issue number1 I
    StatePublished - Feb 1 1996

    ASJC Scopus subject areas

    • Pharmacology (medical)

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