A review of NMDA receptors and the phencyclidine model of schizophrenia

Sheri A. Thornberg; Stephen R. Saklad

A review of NMDA receptors and the phencyclidine model of schizophrenia

Sheri A. Thornberg, Stephen R. Saklad

Research output: Contribution to journal › Review article › peer-review

Abstract

Current models of drug-induced psychosis insufficiently describe the symptoms of schizophrenia. Phencyclidine-induced psychosis is a model that more completely reflects the pathophysiology of the disease. By decreasing glutamatergic neurotransmission, phencyclidine decreases γ-aminobutyric acid release from the nucleus accumbens, striatum, and hippocampus (manifested by MK-801); may inhibit tonic release of dopamine from the nucleus accumbens and striatum, resulting in increased dopamine phasic reactivity; and decreases long-term potentiation. Glutamatergic system dysfunction may be involved, but pharmacologic manipulation has not revealed a clear mechanism of this dysfunction.

Original language	English (US)
Pages (from-to)	82-93
Number of pages	12
Journal	Pharmacotherapy
Volume	16
Issue number	1 I
State	Published - Feb 1 1996

ASJC Scopus subject areas

Pharmacology (medical)

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AB - Current models of drug-induced psychosis insufficiently describe the symptoms of schizophrenia. Phencyclidine-induced psychosis is a model that more completely reflects the pathophysiology of the disease. By decreasing glutamatergic neurotransmission, phencyclidine decreases γ-aminobutyric acid release from the nucleus accumbens, striatum, and hippocampus (manifested by MK-801); may inhibit tonic release of dopamine from the nucleus accumbens and striatum, resulting in increased dopamine phasic reactivity; and decreases long-term potentiation. Glutamatergic system dysfunction may be involved, but pharmacologic manipulation has not revealed a clear mechanism of this dysfunction.

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A review of NMDA receptors and the phencyclidine model of schizophrenia

Abstract

ASJC Scopus subject areas

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