A review of metal-catalyzed molecular damage: Protection by melatonin

Alejandro Romero, Eva Ramos, Cristóbal De Los Ríos, Javier Egea, Javier Del Pino, Russel J. Reiter

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations

Abstract

Metal exposure is associated with several toxic effects; herein, we review the toxicity mechanisms of cadmium, mercury, arsenic, lead, aluminum, chromium, iron, copper, nickel, cobalt, vanadium, and molybdenum as these processes relate to free radical generation. Free radicals can be generated in cells due to a wide variety of exogenous and endogenous processes, causing modifications in DNA bases, enhancing lipid peroxidation, and altering calcium and sulfhydryl homeostasis. Melatonin, an ubiquitous and pleiotropic molecule, exerts efficient protection against oxidative stress and ameliorates oxidative/nitrosative damage by a variety of mechanisms. Also, melatonin has a chelating property which may contribute in reducing metal-induced toxicity as we postulate here. The aim of this review was to highlight the protective role of melatonin in counteracting metal-induced free radical generation. Understanding the physicochemical insights of melatonin related to the free radical scavenging activity and the stimulation of antioxidative enzymes is of critical importance for the development of novel therapeutic strategies against the toxic action of these metals.

Original languageEnglish (US)
Pages (from-to)343-370
Number of pages28
JournalJournal of pineal research
Volume56
Issue number4
DOIs
StatePublished - May 2014

Keywords

  • chelating properties
  • free radicals
  • melatonin
  • metals
  • oxidative stress

ASJC Scopus subject areas

  • Endocrinology

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