A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases

Yang Yang, Yang Sun, Wei Yi, Yue Li, Chongxi Fan, Zhenlong Xin, Shuai Jiang, Shouyin Di, Yan Qu, Russel J. Reiter, Dinghua Yi

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Cardiac tissue loss is one of the most important factors leading to the unsatisfactory recovery even after treatment of ischemic heart disease. Melatonin, a circadian molecule with marked antioxidant properties, protects against ischemia-reperfusion (IR) injury. In particular, the myocardial protection of melatonin is substantial. We initially focus on the cardioprotective effects of melatonin in myocardial IR. These studies showed how melatonin preserves the microstructure of the cardiomyocyte and reduces myocardial IR injury. Thereafter, downstream signaling pathways of melatonin were summarized including Janus kinase 2/signal transducers and activators of transcription 3, nitric oxide-synthase, and nuclear factor erythroid 2 related factor 2. Herein, we propose the clinical applications of melatonin in several ischemic heart diseases. Collectively, the information summarized in this review (based on in vitro, animal, and human studies) should serve as a comprehensive reference for the action of melatonin in cardioprotection and hopefully will contribute to the design of future experimental research.

Original languageEnglish (US)
Pages (from-to)357-366
Number of pages10
JournalJournal of pineal research
Volume57
Issue number4
DOIs
StatePublished - Nov 2014

Keywords

  • Cardioprotection
  • Clinical heart diseases
  • Melatonin
  • Myocardial ischemia-reperfusion injury

ASJC Scopus subject areas

  • Endocrinology

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