TY - JOUR
T1 - A retrospective study evaluating the use of Permacol™ surgical implant in incisional and ventral hernia repair
AU - Chand, Bipan
AU - Indeck, Matthew
AU - Needleman, Bradley
AU - Finnegan, Matthew
AU - Van Sickle, Kent R.
AU - Ystgaard, Brynjulf
AU - Gossetti, Francesco
AU - Pullan, Rupert D.
AU - Giordano, Pasquale
AU - McKinley, Aileen
N1 - Funding Information:
This study was sponsored and entirely funded by Covidien (manufacturer of Permacol™ Surgical Implant).
PY - 2014
Y1 - 2014
N2 - Background: The outcome of incisional and ventral hernia repair depends on surgical technique, patient, and material. Permacol™ surgical implant (crosslinked porcine collagen) has been used for over a decade; however, there are few data on outcomes. This study is the largest retrospective multinational study to date to evaluate outcomes with Permacol™ surgical implant in the repair of incisional and ventral hernias. Methods: Data were collected retrospectively on 343 patients treated for 213 incisional and 130 ventral hernias. Data evaluated included patient demographics, wound classification, surgical technique, morbidity, and recurrence rates. Results: Median follow-up time was 649 days (max: 2857), median age 57 years (range 23-91), and BMI 32 kg/m2 (range 17.6-77.8). Two or more comorbidities were present in 70% of patients. Open surgery was performed in 220 (64%) patients. Permacol™ surgical implant was used as an underlay (250), sublay (39), onlay (37), or inlay (17). Surgical techniques included component separation (89; 25.9%), modified Stoppa technique (197; 57.4%), and Rives-Stoppa (17; 5.0%). CDC Surgical Wound Classification was Class I (190), Class II (103), Class III (28), and Class IV (22). Complications were seen in 40.5% (139) of the patients, with seroma (19%) and wound infection (15%) as the most common. Mesh removal occurred in 1 (0.3%) patient. Kaplan-Meier analysis demonstrated that the probabilities for hernia recurrence at one, two, and three years were 5.8%, 16.6%, and 31.0%, respectively. Conclusions: Permacol™ surgical implant was shown to be safe with relatively low rates of hernia recurrence. Clinical trial registration number: NCT01214252 (http://www.clinicaltrials.gov).
AB - Background: The outcome of incisional and ventral hernia repair depends on surgical technique, patient, and material. Permacol™ surgical implant (crosslinked porcine collagen) has been used for over a decade; however, there are few data on outcomes. This study is the largest retrospective multinational study to date to evaluate outcomes with Permacol™ surgical implant in the repair of incisional and ventral hernias. Methods: Data were collected retrospectively on 343 patients treated for 213 incisional and 130 ventral hernias. Data evaluated included patient demographics, wound classification, surgical technique, morbidity, and recurrence rates. Results: Median follow-up time was 649 days (max: 2857), median age 57 years (range 23-91), and BMI 32 kg/m2 (range 17.6-77.8). Two or more comorbidities were present in 70% of patients. Open surgery was performed in 220 (64%) patients. Permacol™ surgical implant was used as an underlay (250), sublay (39), onlay (37), or inlay (17). Surgical techniques included component separation (89; 25.9%), modified Stoppa technique (197; 57.4%), and Rives-Stoppa (17; 5.0%). CDC Surgical Wound Classification was Class I (190), Class II (103), Class III (28), and Class IV (22). Complications were seen in 40.5% (139) of the patients, with seroma (19%) and wound infection (15%) as the most common. Mesh removal occurred in 1 (0.3%) patient. Kaplan-Meier analysis demonstrated that the probabilities for hernia recurrence at one, two, and three years were 5.8%, 16.6%, and 31.0%, respectively. Conclusions: Permacol™ surgical implant was shown to be safe with relatively low rates of hernia recurrence. Clinical trial registration number: NCT01214252 (http://www.clinicaltrials.gov).
KW - Abdominal wall
KW - Biocompatible materials
KW - Collagen
KW - Hernia
KW - Recurrence
KW - Retrospective studies
KW - Surgical mesh
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U2 - 10.1016/j.ijsu.2014.01.025
DO - 10.1016/j.ijsu.2014.01.025
M3 - Article
C2 - 24508570
AN - SCOPUS:84897405230
SN - 1743-9191
VL - 12
SP - 296
EP - 303
JO - International Journal of Surgery
JF - International Journal of Surgery
IS - 4
ER -