A relationship between increased voluntary alcohol preference and basal hypercorticosteronemia associated with an attenuated rise in corticosterone output during stress

Chandan Prasad, Anand Prasad

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Some of the multiple biological effects of stress include activation of a variety of neuroendocrine systems, resulting in enhanced secretion of many hormones, including corticosterone, as well as facilitation of drug-seeking behavior. Therefore, we have examined the potential relationship between voluntary alcohol consumption (VAC) and corticosterone output profile using: (1) selectively bred alcohol-preferring (P) and nonpreferring (NP) rats; and (2) outbred male Holtzman Sprague-Dawley rats selected for (a) low basal corticosterone (< 2 μg/mg Cr) and high stimulation (> 250%) (L-H rats), and (b) high basal corticosterone (> 4 μg/mg Cr) and low stimulation of corticosterone output on 24-hour fasting stress (< 125%) (H-L rats). The results of this study show: (a) the corticosterone output profiles of P and NP rats were similar to those of H-L and L-H rats, respectively; and (b) the H-L rats exhibited significantly higher VAC than the L-H rats. In conclusion, these data suggest that basal hypercorticosteronemia associated with attenuated rise in corticosterone output during stress may be associated with increased VAC.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalAlcohol
Volume12
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • Alcohol preference
  • Corticosterone
  • HPA-Axis
  • Hypercorticosteronemia
  • Stress

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

Fingerprint

Dive into the research topics of 'A relationship between increased voluntary alcohol preference and basal hypercorticosteronemia associated with an attenuated rise in corticosterone output during stress'. Together they form a unique fingerprint.

Cite this