A relationship between increased voluntary alcohol preference and basal hypercorticosteronemia associated with an attenuated rise in corticosterone output during stress

Chandan Prasad, Anand Prasad

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Some of the multiple biological effects of stress include activation of a variety of neuroendocrine systems, resulting in enhanced secretion of many hormones, including corticosterone, as well as facilitation of drug-seeking behavior. Therefore, we have examined the potential relationship between voluntary alcohol consumption (VAC) and corticosterone output profile using: (1) selectively bred alcohol-preferring (P) and nonpreferring (NP) rats; and (2) outbred male Holtzman Sprague-Dawley rats selected for (a) low basal corticosterone (< 2 μg/mg Cr) and high stimulation (> 250%) (L-H rats), and (b) high basal corticosterone (> 4 μg/mg Cr) and low stimulation of corticosterone output on 24-hour fasting stress (< 125%) (H-L rats). The results of this study show: (a) the corticosterone output profiles of P and NP rats were similar to those of H-L and L-H rats, respectively; and (b) the H-L rats exhibited significantly higher VAC than the L-H rats. In conclusion, these data suggest that basal hypercorticosteronemia associated with attenuated rise in corticosterone output during stress may be associated with increased VAC.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalAlcohol
Volume12
Issue number1
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Alcohol preference
  • Corticosterone
  • HPA-Axis
  • Hypercorticosteronemia
  • Stress

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

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