A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity

S. M. Brown, E. Peet, S. B. Manuck, D. E. Williamson, R. E. Dahl, R. E. Ferrell, A. R. Hariri

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (TPH2) is preferentially involved in the rate-limiting synthesis of neuronal serotonin. Genetic variation in the human TPH2 gene (hTPH2) has been associated with altered in vitro enzyme activity as well as increased risk for mood disorders. Here, we provide the first in vivo evidence that a relatively frequent regulatory variant (G(-844)T) of hTPH2 biases the reactivity of the amygdala, a neural structure critical in the generation and regulation of emotional behaviors.

Original languageEnglish (US)
Pages (from-to)884-888
Number of pages5
JournalMolecular psychiatry
Volume10
Issue number9
DOIs
StatePublished - Sep 2005

Keywords

  • Amygdala
  • Serotonin
  • TPH2
  • fMRI

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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