A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca2+remodeling and cancer hallmarks in colorectal carcinoma cells

Diego Sobradillo; Miriam Hernández-Morales; Daniel Ubierna; Mary P. Moyer; Lucía Núñez; Carlos Villalobos

doi:10.1074/jbc.M114.581678

A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca²⁺remodeling and cancer hallmarks in colorectal carcinoma cells

Diego Sobradillo, Miriam Hernández-Morales, Daniel Ubierna, Mary P. Moyer, Lucía Núñez, Carlos Villalobos

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Results: Colon carcinoma cells show enhanced store-operated Ca2+ entry and currents and depleted Ca2+ stores associated with changes in STIM1/STIM2 ratio and TRPC1.

Conclusion: Ca2+ remodeling in colon cancer is driven by a reciprocal shift in TRPC1 and STIM2.

Significance: STIM1/STIM2 and TRPC1 should be investigated further as novel targets for colon cancer.

Background: Changes in Ca²⁺handling in tumor cells might provide novel targets for cancer.

Original language	English (US)
Pages (from-to)	28765-28782
Number of pages	18
Journal	Journal of Biological Chemistry
Volume	289
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M114.581678
State	Published - Oct 17 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Sobradillo, D., Hernández-Morales, M., Ubierna, D., Moyer, M. P., Núñez, L., & Villalobos, C. (2014). A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca²⁺remodeling and cancer hallmarks in colorectal carcinoma cells. Journal of Biological Chemistry, 289(42), 28765-28782. https://doi.org/10.1074/jbc.M114.581678

A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca²⁺remodeling and cancer hallmarks in colorectal carcinoma cells. / Sobradillo, Diego; Hernández-Morales, Miriam; Ubierna, Daniel et al.
In: Journal of Biological Chemistry, Vol. 289, No. 42, 17.10.2014, p. 28765-28782.

Research output: Contribution to journal › Article › peer-review

Sobradillo, D, Hernández-Morales, M, Ubierna, D, Moyer, MP, Núñez, L & Villalobos, C 2014, 'A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca²⁺remodeling and cancer hallmarks in colorectal carcinoma cells', Journal of Biological Chemistry, vol. 289, no. 42, pp. 28765-28782. https://doi.org/10.1074/jbc.M114.581678

Sobradillo D, Hernández-Morales M, Ubierna D, Moyer MP, Núñez L, Villalobos C. A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca²⁺remodeling and cancer hallmarks in colorectal carcinoma cells. Journal of Biological Chemistry. 2014 Oct 17;289(42):28765-28782. doi: 10.1074/jbc.M114.581678

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abstract = "Results: Colon carcinoma cells show enhanced store-operated Ca2+ entry and currents and depleted Ca2+ stores associated with changes in STIM1/STIM2 ratio and TRPC1.Conclusion: Ca2+ remodeling in colon cancer is driven by a reciprocal shift in TRPC1 and STIM2.Significance: STIM1/STIM2 and TRPC1 should be investigated further as novel targets for colon cancer.Background: Changes in Ca2+handling in tumor cells might provide novel targets for cancer.",

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A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca²⁺remodeling and cancer hallmarks in colorectal carcinoma cells

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