Abstract
A randomized trial of intrapartum versus postpartum antibiotic treatment of women with intra-amniotic infection was conducted. Intra-amniotic infection was treated with ampicillin and gentamicin during labor (at the time of diagnosis) in 26 women and immediately after umbilical cord clamping in 19 women. Intrapartum treatment led to a lower incidence of neonatal sepsis (0 versus 21%; P = .03) and a shorter neonatal hospital stay (3.8 versus 5.7 days; P = .02) when compared with postpartum treatment. There were no significant differences in the microbiologic results, the gestational age, or the birth weight between the groups. Intrapartum-treated mothers had a shorter mean postpartum stay, a lower mean number of febrile days, and a lower mean peak postpartum temperature than did postpartum-treated mothers; these differences were all statistically significant (P = .05). The treatment of clinical intra-amniotic infection during labor results in improved outcome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 823-828 |
| Number of pages | 6 |
| Journal | Obstetrics and Gynecology |
| Volume | 72 |
| Issue number | 6 |
| State | Published - 1988 |
Fingerprint
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
A randomized trial of intrapartum versus immediate postpartum treatment of women with intra-amniotic infection. / Gibbs, R. S.; Dinsmoor, M. J.; Newton, E. R.; Ramamurthy, R. S.
In: Obstetrics and Gynecology, Vol. 72, No. 6, 1988, p. 823-828.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A randomized trial of intrapartum versus immediate postpartum treatment of women with intra-amniotic infection
AU - Gibbs, R. S.
AU - Dinsmoor, M. J.
AU - Newton, E. R.
AU - Ramamurthy, R. S.
PY - 1988
Y1 - 1988
N2 - A randomized trial of intrapartum versus postpartum antibiotic treatment of women with intra-amniotic infection was conducted. Intra-amniotic infection was treated with ampicillin and gentamicin during labor (at the time of diagnosis) in 26 women and immediately after umbilical cord clamping in 19 women. Intrapartum treatment led to a lower incidence of neonatal sepsis (0 versus 21%; P = .03) and a shorter neonatal hospital stay (3.8 versus 5.7 days; P = .02) when compared with postpartum treatment. There were no significant differences in the microbiologic results, the gestational age, or the birth weight between the groups. Intrapartum-treated mothers had a shorter mean postpartum stay, a lower mean number of febrile days, and a lower mean peak postpartum temperature than did postpartum-treated mothers; these differences were all statistically significant (P = .05). The treatment of clinical intra-amniotic infection during labor results in improved outcome.
AB - A randomized trial of intrapartum versus postpartum antibiotic treatment of women with intra-amniotic infection was conducted. Intra-amniotic infection was treated with ampicillin and gentamicin during labor (at the time of diagnosis) in 26 women and immediately after umbilical cord clamping in 19 women. Intrapartum treatment led to a lower incidence of neonatal sepsis (0 versus 21%; P = .03) and a shorter neonatal hospital stay (3.8 versus 5.7 days; P = .02) when compared with postpartum treatment. There were no significant differences in the microbiologic results, the gestational age, or the birth weight between the groups. Intrapartum-treated mothers had a shorter mean postpartum stay, a lower mean number of febrile days, and a lower mean peak postpartum temperature than did postpartum-treated mothers; these differences were all statistically significant (P = .05). The treatment of clinical intra-amniotic infection during labor results in improved outcome.
UR - http://www.scopus.com/inward/record.url?scp=0024157149&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024157149&partnerID=8YFLogxK
M3 - Article
C2 - 3186087
AN - SCOPUS:0024157149
VL - 72
SP - 823
EP - 828
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 6
ER -