A randomized trial of intrapartum versus immediate postpartum treatment of women with intra-amniotic infection

R. S. Gibbs, M. J. Dinsmoor, E. R. Newton, R. S. Ramamurthy

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

A randomized trial of intrapartum versus postpartum antibiotic treatment of women with intra-amniotic infection was conducted. Intra-amniotic infection was treated with ampicillin and gentamicin during labor (at the time of diagnosis) in 26 women and immediately after umbilical cord clamping in 19 women. Intrapartum treatment led to a lower incidence of neonatal sepsis (0 versus 21%; P = .03) and a shorter neonatal hospital stay (3.8 versus 5.7 days; P = .02) when compared with postpartum treatment. There were no significant differences in the microbiologic results, the gestational age, or the birth weight between the groups. Intrapartum-treated mothers had a shorter mean postpartum stay, a lower mean number of febrile days, and a lower mean peak postpartum temperature than did postpartum-treated mothers; these differences were all statistically significant (P = .05). The treatment of clinical intra-amniotic infection during labor results in improved outcome.

Original languageEnglish (US)
Pages (from-to)823-828
Number of pages6
JournalObstetrics and Gynecology
Volume72
Issue number6
StatePublished - 1988

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Postpartum Period
Infection
Mothers
Therapeutics
Umbilical Cord
Ampicillin
Gentamicins
Birth Weight
Constriction
Gestational Age
Length of Stay
Fever
Anti-Bacterial Agents
Temperature
Incidence

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Gibbs, R. S., Dinsmoor, M. J., Newton, E. R., & Ramamurthy, R. S. (1988). A randomized trial of intrapartum versus immediate postpartum treatment of women with intra-amniotic infection. Obstetrics and Gynecology, 72(6), 823-828.

A randomized trial of intrapartum versus immediate postpartum treatment of women with intra-amniotic infection. / Gibbs, R. S.; Dinsmoor, M. J.; Newton, E. R.; Ramamurthy, R. S.

In: Obstetrics and Gynecology, Vol. 72, No. 6, 1988, p. 823-828.

Research output: Contribution to journalArticle

Gibbs, RS, Dinsmoor, MJ, Newton, ER & Ramamurthy, RS 1988, 'A randomized trial of intrapartum versus immediate postpartum treatment of women with intra-amniotic infection', Obstetrics and Gynecology, vol. 72, no. 6, pp. 823-828.
Gibbs, R. S. ; Dinsmoor, M. J. ; Newton, E. R. ; Ramamurthy, R. S. / A randomized trial of intrapartum versus immediate postpartum treatment of women with intra-amniotic infection. In: Obstetrics and Gynecology. 1988 ; Vol. 72, No. 6. pp. 823-828.
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