A random signal model for cDNA microarrays

Y. Balagurunathan, E. R. Dougherty, Y. Chen, M. L. Bitter, J. M. Trent

Research output: Contribution to journalArticlepeer-review

Abstract

The images resulting from cDNA microarrays are highly random. There are many aspects to this randomness, including spot size, shape, intensity, uniformity, and circularity, as well as both foreground and background noise. This paper presents a random model for the generation of microarray images. The model is complicated and contains over twenty parameters. It can be used to test microarray imaging algorithms and to simulate the effects of various dependencies within the image formation process.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalProceedings of SPIE-The International Society for Optical Engineering
Volume4266
DOIs
StatePublished - 2001

Keywords

  • Random model
  • Simulated cDNA microarray
  • cDNA spot model

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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