A radiation hybrid map of 40 loci for the distal long arm of human chromosome 8

Tracey B. Lewis, Lesa Nelson, Ken Ward, Robin J. Leach

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We generated a panel of 97 radiation hybrids from the cell line GM10156B, which contains only human chromosome 8 in a Chinese hamster ovary cell line background. Statistical analysis of the cosegregation of markers in the 97 radiation hybrids was used to construct a physical map delineating the order and intermarker distance of 40 8q24 loci. Twenty one loci were ordered with maximum likelihood ratios greater than 1000:1. A high level of consistancy was seen between our RH map and the published genetic map, suggesting that our panel will be a valuable resource for the rapid mapping of markers derived from human chromosome 8.

Original languageEnglish (US)
Pages (from-to)334-341
Number of pages8
JournalGenome Research
Volume5
Issue number4
DOIs
StatePublished - Nov 1995

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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